Mark M. Davis

TL;DR: It is found that the V(D)J junction or ‘CDR3' portion of TCRα and β seem most important in contacting peptides bound to MHC molecules, consistent with previous predictions.

TL;DR: A number of recent developments in this technology have made these multimers much easier to make and use in large numbers, and enrichment techniques have provided a greatly increased sensitivity that allows the analysis of the naive T cell repertoire directly.

TL;DR: Data suggest that CD4 engagement occurs after a TCR-peptide/MHC complex has formed and that it requires a certain minimal half-life of the ternary complex to be fully engaged in signaling.

TL;DR: T-ATAC-seq is a new tool that enables analysis of epigenomic landscapes in clonal T cells and should be valuable for studies of T cell malignancy, immunity and immunotherapy.

TL;DR: In silico quantification of cell proportions from mixed-cell transcriptomics data (deconvolution) requires a reference expression matrix, called basis matrix, and introduces immunoStates, a basis matrix built using 6160 samples with different disease states across 42 microarray platforms that significantly reduces biological and technical biases.