M
Mark M. Davis
Researcher at Stanford University
Publications - 623
Citations - 84251
Mark M. Davis is an academic researcher from Stanford University. The author has contributed to research in topics: T cell & T-cell receptor. The author has an hindex of 144, co-authored 581 publications receiving 74358 citations. Previous affiliations of Mark M. Davis include Washington University in St. Louis & University of Chicago.
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Journal ArticleDOI
TCR–peptide–MHC interactions in situ show accelerated kinetics and increased affinity
Johannes B. Huppa,Markus Axmann,Manuel A. Mörtelmaier,Manuel A. Mörtelmaier,Manuel A. Mörtelmaier,Björn F. Lillemeier,Björn F. Lillemeier,Evan W. Newell,Mario Brameshuber,Lawrence O. Klein,Gerhard J. Schütz,Mark M. Davis,Mark M. Davis +12 more
TL;DR: It is shown that synaptic TCR–pMHC binding dynamics differ significantly from TCR’s binding in solution, and TCR affinity for pMHC was significantly elevated as the result of a large (about 100-fold) increase in the association rate, a likely consequence of complementary molecular orientation and clustering.
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Linking T-cell receptor sequence to functional phenotype at the single-cell level
TL;DR: This method involves sequencing of TCRα and TCRβ genes, and amplifying functional genes characteristic of different T cell subsets, in single T cells, and applies it to study the clonal ancestry and differentiation of T lymphocytes infiltrating a human colorectal carcinoma.
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Deconstructing the Peptide-MHC Specificity of T Cell Recognition
Michael E. Birnbaum,Juan L. Mendoza,Sethi Dhruv Kam,Shen Dong,Jacob Glanville,Jessica Dobbins,Engin Özkan,Mark M. Davis,Kai W. Wucherpfennig,K. Christopher Garcia +9 more
TL;DR: The mechanistic basis of TCR cross-reactivity described here enables effective surveillance of diverse self and foreign antigens without necessitating degenerate recognition of nonhomologous peptides.
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CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4 + T cells
Jeffrey C. Rathmell,Michael P. Cooke,William Y. Ho,Jeff Grein,Sarah E. Townsend,Mark M. Davis,Christopher C. Goodnow +6 more
TL;DR: This work tracks the outcome of in vivo interactions between B cells and CD4+T cells that recognize a transgene-encoded autoantigen, hen egg lysozyme, using cells from mice trans-genic for immunoglobulin and T-cell receptor (TCR) genes.
Journal ArticleDOI
A third type of murine T-cell receptor gene
Yueh-hsiu Chien,Daniel M. Becker,Tullia Lindsten,Maki Okamura,David I. Cohen,David I. Cohen,Mark M. Davis +6 more
TL;DR: A new species of T-cell receptor cDNA clone whose predicted amino acid sequence has homology to variable, constant, joining and diversity segments of immunoglobulins and T- cell receptors is isolated.