M
Mark M. Davis
Researcher at Stanford University
Publications - 623
Citations - 84251
Mark M. Davis is an academic researcher from Stanford University. The author has contributed to research in topics: T cell & T-cell receptor. The author has an hindex of 144, co-authored 581 publications receiving 74358 citations. Previous affiliations of Mark M. Davis include Washington University in St. Louis & University of Chicago.
Papers
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Journal ArticleDOI
Plasma membrane-associated proteins are clustered into islands attached to the cytoskeleton.
TL;DR: Transmission electron microscopy of plasma membrane sheets and specific probes are used to show that most or all plasma membrane-associated proteins are clustered in cholesterol-enriched domains (“islands”) that are separated by “protein-free” and cholesterol-low membrane.
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Initiation of Signal Transduction through the T Cell Receptor Requires the Multivalent Engagement of Peptide/MHC Ligands
J. Jay Boniface,Joshua D. Rabinowitz,Christoph Wülfing,Johannes Hampl,Ziv Reich,John D. Altman,Ronald M. Kantor,Craig Beeson,Harden M. McConnell,Mark M. Davis,Mark M. Davis +10 more
TL;DR: It is found that agonist peptide/MHC ligands are nonstimulatory as monomers and minimally stimulatory as dimers and trimeric or tetrameric agonist ligands that engage multiple TCRs for a sustained duration are potent stimuli.
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Low affinity interaction of peptide-MHC complexes with T cell receptors
TL;DR: The binding to T cells of a labeled monoclonal antibody to the TCR was inhibited by soluble class II MHC heterodimers complexed to different peptides, suggesting that antigen-independent adhesion precedes TCR engagement.
Journal ArticleDOI
Differential Clustering of CD4 and CD3ζ During T Cell Recognition
TL;DR: The CD4 coreceptor may serve primarily to "boost" recognition of ligand by the TCR and may not be required once activation has been initiated.
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Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand.
Leslie J. Berg,Ann M. Pullen,Barbara Fazekas de St Groth,Diane Mathis,Diane Mathis,Christophe Benoist,Christophe Benoist,Mark M. Davis,Mark M. Davis +8 more
TL;DR: Data suggest that a direct T cell receptor-MHC interaction occurs in the thymus in the absence of nominal antigen and results in the enhanced export of T cells, consistent with the concept of "positive selection".