Mark M. Davis

TL;DR: Characterization of cDNA and genomic clones encoding the Beta chain of the T-cell receptor for antigen reveals a very close resemblance to immunoglobulin: V, D, J, and C elements; the mechanism of rearrangement; and the potential extent of diversity, explaining the relatively large T- cell repertoire of specificities and the clonal nature of individual responses.

TL;DR: It is discovered that closely related B cells often switch to the same class, but lose coherence as somatic mutations accumulate, suggesting that class switch recombination is directed toward specific isotypes by a cell-autonomous imprinted state.

TL;DR: The sequence of events and the development of techniques required to observe these events have significantly enhanced the understanding of T cell recognition and may find application in other systems of transient cell:cell interactions as well.

TL;DR: In a T cell receptor transgenic mouse model of thymic selection, the efficiency of selection of the transgenic alpha beta heterodimer is significantly enhanced in animals that express higher densities of the relevant major histocompatibility complex molecule (I-Ek/b), implying that there is a stochastic component to positive selection in the thymus.

TL;DR: Overall, the findings provide a quantitative characterization of O-GlcNAc glycoproteins and their corresponding modification sites in primary human T cells, which will facilitate mechanistic studies into the function ofO-GlCNAc in T cell activation.