M
Mark M. Davis
Researcher at Stanford University
Publications - 623
Citations - 84251
Mark M. Davis is an academic researcher from Stanford University. The author has contributed to research in topics: T cell & T-cell receptor. The author has an hindex of 144, co-authored 581 publications receiving 74358 citations. Previous affiliations of Mark M. Davis include Washington University in St. Louis & University of Chicago.
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Ligand-specific oligomerization of T-cell receptor molecules
TL;DR: QELS is used to show that, in the presence of MHC molecules bound to a full agonist peptide, TCR/peptide–MHC complexes oligomerize in solution to form supramolecular structures at concentrations near the dissociation constant of the binding reaction.
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Single-Cell Chromatin Modification Profiling Reveals Increased Epigenetic Variations with Aging
Peggie Cheung,Francesco Vallania,Hayley Warsinske,Michele Donato,Steven Schaffert,Sarah E. Chang,Mai Dvorak,Cornelia L. Dekker,Mark M. Davis,Paul J. Utz,Purvesh Khatri,Alex J. Kuo +11 more
TL;DR: A highly multiplexed mass cytometry analysis is employed to profile the global levels of a broad array of chromatin modifications in primary human immune cells at the single-cell level and demonstrates that aging-related chromatin alterations are predominantly driven by non-heritable influences.
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Automatic Classification of Cellular Expression by Nonlinear Stochastic Embedding (ACCENSE)
TL;DR: ACCENSE (Automatic Classification of Cellular Expression by Nonlinear Stochastic Embedding), a tool that computes a two-dimensional nonlinear distillation of the raw data, and automatically stratifies cells into phenotypic subpopulations based on their distribution of markers, is described.
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Clonal Deletion Prunes but Does Not Eliminate Self-Specific αβ CD8+ T Lymphocytes
Wong Yu,Ning Jiang,Peter J.R. Ebert,Brian A. Kidd,Sabina Müller,Peder Lund,Jeremy Juang,Keishi Adachi,Tiffany Tse,Michael E. Birnbaum,Evan W. Newell,Darrell M. Wilson,Gijsbert M. Grotenbreg,Salvatore Valitutti,Stephen R. Quake,Mark M. Davis +15 more
TL;DR: The conclusion is that clonal deletion prunes but does not eliminate self-specific T cells and it is suggested that to do so would create holes in the repertoire that pathogens could readily exploit.
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Antigen Identification for Orphan T Cell Receptors Expressed on Tumor-Infiltrating Lymphocytes.
Marvin H. Gee,Arnold Han,Shane Lofgren,John F. Beausang,Juan L. Mendoza,Michael E. Birnbaum,Michael T. Bethune,Suzanne Fischer,Xinbo Yang,Raquel Gomez-Eerland,David B. Bingham,Leah V. Sibener,Ricardo A. Fernandes,Andrew Velasco,David Baltimore,Ton N. Schumacher,Purvesh Khatri,Stephen R. Quake,Mark M. Davis,K. Christopher Garcia +19 more
TL;DR: It is shown that the exposed recognition surface of MHC-bound peptides accessible to the TCR contains sufficient structural information to enable the reconstruction of sequences of peptide targets for pathogenic TCRs of unknown specificity.