Matthew Blades

TL;DR: Using a genome-wide screen of 9.6 million genetic variants achieved through 1000 Genomes Project imputation in 62,166 samples, association to lipid traits in 93 loci is identified, including 79 previously identified loci with new lead SNPs and 10 new loci, including 15 locu with a low-frequency lead SNP and 10 loco with a missense lead SNP.

TL;DR: This work demonstrates distinct virulence in experimental infection and in vivo selection for switching between SpnD39III variants, which is ubiquitous in pneumococci, indicating an essential role in its biology.

TL;DR: This study demonstrates that 1000G imputation and genetic fine-mapping of common and low-frequency variant association signals at GWAS loci, integrated with genomic annotation in relevant tissues, can provide insight into the functional and regulatory mechanisms through which their effects on glycaemic and obesity-related traits are mediated.

TL;DR: It is shown that Histone Deacetylase 1 and 2 (HDAC1/2), the catalytic core of numerous co-repressor complexes, are important histone decrotonylase enzymes.

TL;DR: It is shown that colorectal cancers (CRCs) display negligible expression of OTC and, in subset of cases, ASS1 proteins, and arginase antagonizes chemotherapeutic drugs oxaliplatin and 5-fluorouracil (5-FU), whereas ADI-PEG20 synergizes with oxali platin in ASS1-negative cell lines and appears to interact with 5- fluorourACil independently of ASS1 status.