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Amy Dressen
Researcher at Genentech
Publications - 21
Citations - 909
Amy Dressen is an academic researcher from Genentech. The author has contributed to research in topics: Genome-wide association study & Expression quantitative trait loci. The author has an hindex of 8, co-authored 20 publications receiving 570 citations.
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Journal ArticleDOI
Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis.
Richard J. Allen,Beatriz Guillen-Guio,Justin M. Oldham,Shwu-Fan Ma,Amy Dressen,Megan L. Paynton,Luke M. Kraven,Ma'en Obeidat,Xuan Li,Michael Ng,Rebecca Braybrooke,Maria Molina-Molina,Maria Molina-Molina,Brian D. Hobbs,Rachel K. Putman,Phuwanat Sakornsakolpat,Helen Booth,William A. Fahy,Simon P. Hart,Michael Hill,Nik Hirani,Richard Hubbard,Robin J. McAnulty,Ann B. Millar,Vidyia Navaratnam,Eunice Oballa,Helen Parfrey,Gauri Saini,Moira K. B. Whyte,Yingze Zhang,Naftali Kaminski,Ayodeji Adegunsoye,Mary E. Strek,Margaret Neighbors,Xuting R. Sheng,Gunnar Gudmundsson,Vilmundur Gudnason,Hiroto Hatabu,David J. Lederer,Ani Manichaikul,John D. Newell,John D. Newell,George T. O'Connor,George T. O'Connor,Victor E. Ortega,Hanfei Xu,Tasha E. Fingerlin,Yohan Bossé,Ke Hao,Philippe Joubert,David C. Nickle,Don D. Sin,Wim Timens,Wim Timens,Dominic Furniss,Andrew P. Morris,Andrew P. Morris,Krina T. Zondervan,Ian P. Hall,Ian P. Hall,Ian Sayers,Ian Sayers,Martin D. Tobin,Martin D. Tobin,Toby M. Maher,Toby M. Maher,Michael H. Cho,Gary M. Hunninghake,David A. Schwartz,Brian L. Yaspan,Philip L. Molyneaux,Philip L. Molyneaux,Carlos Flores,Imre Noth,R. Gisli Jenkins,R. Gisli Jenkins,Louise V. Wain,Louise V. Wain +77 more
TL;DR: The observation that decreased DEPTOR expression associates with increased susceptibility to IPF supports recent studies demonstrating the importance of mTOR signaling in lung fibrosis, and new signals of association implicating KIF15 and MAD1L1 suggest a possible role of mitotic spindle-assembly genes in IPF susceptibility.
Journal ArticleDOI
SNP-mediated disruption of CTCF binding at the IFITM3 promoter is associated with risk of severe influenza in humans
E. Kaitlynn Allen,Adrienne G. Randolph,Tushar Bhangale,Pranay Dogra,Maikke B. Ohlson,Christine M. Oshansky,Christine M. Oshansky,Anthony E. Zamora,John P. Shannon,David Finkelstein,Amy Dressen,John P. DeVincenzo,John P. DeVincenzo,Miguela A. Caniza,Ben Youngblood,Carrie M. Rosenberger,Paul G. Thomas +16 more
TL;DR: A role for rs34481144 is determined as an expression quantitative trait locus (eQTL) for IFITM3, with the risk allele associated with lower mRNA expression, and a new regulator of IFITm3 expression that associates with CD8+ T cell levels in the airways and a spectrum of clinical outcomes is identified.
Journal ArticleDOI
Targeting factor D of the alternative complement pathway reduces geographic atrophy progression secondary to age-related macular degeneration.
Brian L. Yaspan,David F. Williams,Frank G. Holz,Carl D. Regillo,Zhengrong Li,Amy Dressen,Menno van Lookeren Campagne,Kha Le,Robert R. Graham,Tatiana Beres,Tushar Bhangale,Lee Honigberg,Ashley M. Smith,Erin C. Henry,Carole Ho,Erich C. Strauss +15 more
TL;DR: The MAHALO study shows a potential treatment effect in patients with geographic atrophy and supports therapeutic targeting of the alternative complement pathway for treating AMD pathogenesis.
Journal ArticleDOI
Integration of eQTL and a Single-Cell Atlas in the Human Eye Identifies Causal Genes for Age-Related Macular Degeneration.
Luz D. Orozco,Hsu-Hsin Chen,Christian Cox,Kenneth J. Katschke,Rommel Arceo,Carmina Espiritu,Patrick Caplazi,Sarajane Saturnio Nghiem,Ying-Jiun Chen,Zora Modrusan,Amy Dressen,Leonard D. Goldstein,Christine Clarke,Tushar Bhangale,Brian L. Yaspan,Marion Jeanne,Michael J. Townsend,Menno van Lookeren Campagne,Jason A. Hackney +18 more
TL;DR: 15 putative causal genes for AMD are identified on the basis of co-localization of genetic association signals for AMD risk and eye eQTL, including the genes TSPAN10 and TRPM1.
Journal ArticleDOI
Analysis of protein-altering variants in telomerase genes and their association with MUC5B common variant status in patients with idiopathic pulmonary fibrosis: a candidate gene sequencing study
Amy Dressen,Alexander R. Abbas,Christopher R. Cabanski,Janina Reeder,Thirumalai R. Ramalingam,Margaret Neighbors,Tushar Bhangale,Matthew J. Brauer,Julie Hunkapiller,Jens Reeder,Kiran Mukhyala,Karen Cuenco,Jennifer Tom,Amy Cowgill,Jan Vogel,William F. Forrest,Harold R. Collard,Paul J. Wolters,Jonathan A. Kropski,Jonathan A. Kropski,Lisa Lancaster,Timothy S. Blackwell,Timothy S. Blackwell,Joseph R. Arron,Brian L. Yaspan +24 more
TL;DR: Blood samples from patients aged 40 years or older and of European ancestry with sporadic IPF are assessed to assess whether rare protein-altering variants in genes regulating telomere length are enriched in patients with IPF homozygous for the non-risk alleles at rs35705950.