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Nancy A. Jenkins
Researcher at Houston Methodist Hospital
Publications - 743
Citations - 105243
Nancy A. Jenkins is an academic researcher from Houston Methodist Hospital. The author has contributed to research in topics: Gene & Gene mapping. The author has an hindex of 155, co-authored 741 publications receiving 101587 citations. Previous affiliations of Nancy A. Jenkins include Institute of Molecular and Cell Biology & University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer.
Richard Fishel,Mary Kay Lescoe,M.R.S. Rao,Neal G. Copeland,Nancy A. Jenkins,Judy Garber,Michael F. Kane,Richard D. Kolodner +7 more
TL;DR: Data and reports indicating that S. cerevisiae msh2 mutations cause an instability of dinucleotide repeats like those associated with H NPCC suggest that hMSH2 is the HNPCC gene.
Journal ArticleDOI
An efficient recombination system for chromosome engineering in Escherichia coli
TL;DR: A recombination system has been developed for efficient chromosome engineering in Escherichia coli by using electroporated linear DNA using a defective lambda prophage, which will be especially useful for the engineering of large bacterial plasmids such as those from bacterial artificial chromosome libraries.
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Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
Andrew V. Biankin,Andrew V. Biankin,Andrew V. Biankin,Nicola Waddell,Karin S. Kassahn,Marie-Claude Gingras,Lakshmi Muthuswamy,Amber L. Johns,David Miller,Peter Wilson,Ann-Marie Patch,Jianmin Wu,David K. Chang,David K. Chang,David K. Chang,Mark J. Cowley,Brooke Gardiner,Sarah Song,Ivon Harliwong,Senel Idrisoglu,Craig Nourse,Ehsan Nourbakhsh,Suzanne Manning,Shivangi Wani,Milena Gongora,Marina Pajic,Christopher J. Scarlett,Christopher J. Scarlett,Anthony J. Gill,Anthony J. Gill,Anthony J. Gill,Andreia V. Pinho,Ilse Rooman,Matthew J. Anderson,Oliver Holmes,Conrad Leonard,Darrin Taylor,Scott Wood,Qinying Xu,Katia Nones,J. Lynn Fink,Angelika N. Christ,Timothy J. C. Bruxner,Nicole Cloonan,Gabriel Kolle,Felicity Newell,Mark Pinese,R. Scott Mead,R. Scott Mead,Jeremy L. Humphris,Warren Kaplan,Marc D. Jones,Emily K. Colvin,Adnan Nagrial,Emily S. Humphrey,Angela Chou,Angela Chou,Venessa T. Chin,Lorraine A. Chantrill,Amanda Mawson,Jaswinder S. Samra,James G. Kench,James G. Kench,James G. Kench,Jessica A. Lovell,Roger J. Daly,Neil D. Merrett,Neil D. Merrett,Christopher W. Toon,Krishna Epari,Nam Q. Nguyen,Andrew Barbour,Nikolajs Zeps,Nipun Kakkar,Fengmei Zhao,Yuan Qing Wu,Min Wang,Donna M. Muzny,William E. Fisher,F. Charles Brunicardi,Sally E. Hodges,Jeffrey G. Reid,Jennifer Drummond,Kyle Chang,Yi Han,Lora Lewis,Huyen Dinh,Christian J. Buhay,Timothy Beck,Lee Timms,Michelle Sam,Kimberly Begley,Andrew M.K. Brown,Deepa Pai,Ami Panchal,Nicholas Buchner,Richard de Borja,Robert E. Denroche,Christina K. Yung,Stefano Serra,Nicole Onetto,Debabrata Mukhopadhyay,Ming-Sound Tsao,Patricia Shaw,Gloria M. Petersen,Steven Gallinger,Steven Gallinger,Ralph H. Hruban,Anirban Maitra,Christine A. Iacobuzio-Donahue,Richard D. Schulick,Christopher L. Wolfgang,Richard A. Morgan,Rita T. Lawlor,Paola Capelli,Vincenzo Corbo,Maria Scardoni,Giampaolo Tortora,Margaret A. Tempero,Karen M. Mann,Nancy A. Jenkins,Pedro A. Perez-Mancera,David J. Adams,David A. Largaespada,Lodewyk F. A. Wessels,Alistair G. Rust,Lincoln Stein,David A. Tuveson,Neal G. Copeland,Elizabeth A. Musgrove,Elizabeth A. Musgrove,Aldo Scarpa,James R. Eshleman,Thomas J. Hudson,Robert L. Sutherland,Robert L. Sutherland,David A. Wheeler,John V. Pearson,John Douglas Mcpherson,Richard A. Gibbs,Sean M. Grimmond +140 more
TL;DR: It is found that frequent and diverse somatic aberrations in genes described traditionally as embryonic regulators of axon guidance, particularly SLIT/ROBO signalling, are also evident in murine Sleeping Beauty transposon-mediated somatic mutagenesis models of pancreatic cancer, providing further supportive evidence for the potential involvement ofAxon guidance genes in pancreatic carcinogenesis.
Journal ArticleDOI
Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand
Tomohiro Takahashi,Masato Tanaka,Camllynn I. Brannan,Nancy A. Jenkins,Neal G. Copeland,Takashi Suda,Shigekazu Nagata +6 more
TL;DR: The results indicate that lpr and gld are mutations in Fas and Fasl, respectively, and suggest important roles of the Fas system in development of T cells as well as cytotoxic T lymphocyte-mediated cytotoxicity.
Journal ArticleDOI
Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo
David R. Borchelt,Gopal Thinakaran,Christopher B. Eckman,Christopher B. Eckman,Michael K. Lee,Frances Davenport,Tamara Ratovitsky,Cristian Mihail Prada,Grace Kim,Sophia Seekins,Debra Yager,Hilda H. Slunt,Rong Wang,Mary Seeger,Allan I. Levey,Sam Gandy,Neal G. Copeland,Nancy A. Jenkins,Donald L. Price,Steven G. Younkin,Steven G. Younkin,Sangram S. Sisodia +21 more
TL;DR: These studies provide compelling support for the view that one mechanism by which these mutant PS1 cause AD is by increasing the extracellular concentration of Abeta peptides terminating at 42(43), species that foster Abeta deposition.