P
Patrick L. McGeer
Researcher at University of British Columbia
Publications - 569
Citations - 61292
Patrick L. McGeer is an academic researcher from University of British Columbia. The author has contributed to research in topics: Microglia & Alzheimer's disease. The author has an hindex of 122, co-authored 569 publications receiving 58584 citations. Previous affiliations of Patrick L. McGeer include Laval University & Kyoto University.
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Common mechanisms involved in Alzheimer's disease and type 2 diabetes: a key role of chronic bacterial infection and inflammation
TL;DR: Accumulation of amylin deposits in type 2 diabetes may result from an innate immune response to chronic bacterial infections, which are known to be associated with amyloidosis, according to epidemiologic evidence and common molecular mechanisms.
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A Method for Diagnosing Alzheimer's Disease Based on Salivary Amyloid-β Protein 42 Levels.
TL;DR: It is reported here that Aβ42 is produced in all peripheral organs tested, thus establishing the generality of its production and establishing that salivary A β42 levels can be used to diagnose AD as well as to predict the risk of its future onset.
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Activated human microglia stimulate neuroblastoma cells to upregulate production of beta amyloid protein and tau: implications for Alzheimer's disease pathogenesis
TL;DR: The data indicate that reactive microglia play an important role in governing the expression of Aβ and tau, and therefore the progression of AD, and provide further evidence that appropriate anti-inflammatory treatment should be beneficial in AD.
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Familial nature and continuing morbidity of the amyotrophic lateral sclerosis-parkinsonism dementia complex of Guam
TL;DR: Data indicate that tangles, as well as plaques, generate inflammatory reactions and that such reactions may exacerbate the fundamental pathology in bodig as wellAs in AD.
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Possible Changes in Striatal and Limbic Cholinergic Systems in Schizophrenia
TL;DR: An alternative hypothesis proposes that the high levels are a compensatory response to defective cholinergic receptors in the affected areas, and by analogy with chorea, dopaminergic antagonists would act in schizophrenia by helping to reestablish cholinerential-dopaminergic balance.