P
Patrick L. McGeer
Researcher at University of British Columbia
Publications - 569
Citations - 61292
Patrick L. McGeer is an academic researcher from University of British Columbia. The author has contributed to research in topics: Microglia & Alzheimer's disease. The author has an hindex of 122, co-authored 569 publications receiving 58584 citations. Previous affiliations of Patrick L. McGeer include Laval University & Kyoto University.
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Axonal damage and demyelination in the white matter after chronic cerebral hypoperfusion in the rat
Hideaki Wakita,Hidekazu Tomimoto,Ichiro Akiguchi,Akinori Matsuo,Jin Xi Lin,Masafumi Ihara,Patrick L. McGeer +6 more
TL;DR: Examination of immunohistochemistry for APP, CgA, and EP is far superior to routine histological staining in sensitivity and may become a useful tool to investigate WM lesions caused by various pathoetiologies.
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Astrocytes produce the antiinflammatory and neuroprotective agent hydrogen sulfide
TL;DR: Data indicate that H(2)S is an endogenous antiinflammatory and neuroprotective agent under the synthetic control of CBS and may have therapeutic potential in neurodegenerative disorders of aging such as Alzheimer disease and Parkinson disease.
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Choline acetylase and glutamic acid decarboxylase in Huntington's chorea. A preliminary study.
TL;DR: Preliminary data is obtained indicating some possible abnormalities in choreic patients in both choline acetylase, the enzyme responsible for acetylcholine synthesis, and in glutamic acid decarboxylase (GAD), the enzymeresponsible for gammaaminobutyric acid (GABA) synthesis.
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Antidepressants inhibit interferon-γ-induced microglial production of IL-6 and nitric oxide
Sadayuki Hashioka,Andis Klegeris,Akira Monji,Takahiro A. Kato,Makoto Sawada,Patrick L. McGeer,Shigenobu Kanba +6 more
TL;DR: It is suggested that antidepressants have inhibitory effects on IFN-γ-activated microglia and these effects are, at least partially, mediated by the cAMP-dependent PKA pathway.
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Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes
Judith Miklossy,Hong Qing,Aleksandra Radenovic,Andras Kis,Bertrand Vileno,Forró Làszló,Lisa Karen Miller,Ralph N. Martins,Gérard Waeber,Vincent Mooser,Fred T. Bosman,Kamel Khalili,Nune Darbinian,Nune Darbinian,Patrick L. McGeer +14 more
TL;DR: It is concluded that Abeta deposits and hyperphosphorylated tau are also associated with type 2 diabetes, highlighting common pathogenetic features in neurodegenerative disorders, including AD and type 1 diabetes, and suggesting that Abetas deposits andhyperphosphories may also occur in other organs than the brain.