P
Patrick L. McGeer
Researcher at University of British Columbia
Publications - 569
Citations - 61292
Patrick L. McGeer is an academic researcher from University of British Columbia. The author has contributed to research in topics: Microglia & Alzheimer's disease. The author has an hindex of 122, co-authored 569 publications receiving 58584 citations. Previous affiliations of Patrick L. McGeer include Laval University & Kyoto University.
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TDP-43 pathology in familial British dementia
TL;DR: Using a variety of antibodies against phosphorylated and non-phosphorylated TDP-43 epitopes, intense accumulation occurred in the form of dystrophic neurites, neuronal cytoplasmic inclusions and was also occasionally associated with neurofibrillary tangles.
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Membrane-bound choline acetyltransferase from human brain: purification and properties.
TL;DR: Immunoblot autoradiography showed that an antiserum prepared previously against soluble ChAT also cross-reacted with both bands of mChAT, indicating that both forms of this enzyme are related.
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Acidic fibroblast growth factor-like immunoreactivity in rat brain following cerebral infarction
Yasushi Hara,Ikuo Tooyama,Osamu Yasuhara,Haruhiko Akiyama,Patrick L. McGeer,Jyoji Handa,Hiroshi Kimura +6 more
TL;DR: The present results suggest that aFGF may be involved in the repair processes following brain infarction.
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Variable Deposition of Amyloid β-Protein (Aβ) with the Carboxy-Terminus that Ends at Residue Valine40 (Aβ40) in the Cerebral Cortex of Patients with Alzheimer's Disease: A Double-Labeling Immunohistochemical Study with Antibodies Specific for Aβ40 and the Aβ that Ends at Residues Alanine42/Threonine43 (Aβ42)
Haruhiko Akiyama,Hiroshi Mori,Naruhiko Sahara,Hiromi Kondo,Kenji Ikeda,Toru Nishimura,Tatsuro Oda,Patrick L. McGeer +7 more
TL;DR: In this paper, the carboxy terminal sequences of Amyloid β-protein (Aβ) deposits in the cerebral cortices of patients with Alzheimer's disease (AD) were investigated immunohistochemically to determine their carboxys terminal sequences.
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Ornithine aminotransferase in Huntington's disease
TL;DR: Ornithine aminotransferase activities in Huntington's disease (HD) brains were found to be reduced, when compared to age-matched control brains, by 34-49% in the frontal cortex, parietal cortex, caudate nucleus and putamen.