P
Patrick L. McGeer
Researcher at University of British Columbia
Publications - 569
Citations - 61292
Patrick L. McGeer is an academic researcher from University of British Columbia. The author has contributed to research in topics: Microglia & Alzheimer's disease. The author has an hindex of 122, co-authored 569 publications receiving 58584 citations. Previous affiliations of Patrick L. McGeer include Laval University & Kyoto University.
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Inflammation, autotoxicity and Alzheimer disease
TL;DR: In this paper, the effects of inflammatory stimulators in Alzheimer's disease (AD) have been investigated and some theoretical opportunities are suggested, based on intervention in the action of the above mentioned mediators.
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A glutamatergic corticostriatal path
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NSAIDs and Alzheimer disease: Epidemiological, animal model and clinical studies
TL;DR: This review reports correlations between four independent fields related to inflammation and Alzheimer disease: fundamental pathology, epidemiology, transgenic animal studies and clinical trials, which show results of clinical investigations have so far been disappointing but have nevertheless correlated with fundamental pathological findings and with transgenic mouse results.
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Inflammatory processes in Alzheimer's disease
TL;DR: Brain phenomena combined with epidemiological evidence of a protective effect of antiinflammatory agents suggest that such agents may have a role to play in treating the disease.
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Immune system response in Alzheimer's disease.
TL;DR: It is established that astrocytes, which are GFAP positive, do not express MHC antigens in Alzheimer's disease, and that reactive microglia and some leukocytes express class II antigen.