P
Patrick L. McGeer
Researcher at University of British Columbia
Publications - 569
Citations - 61292
Patrick L. McGeer is an academic researcher from University of British Columbia. The author has contributed to research in topics: Microglia & Alzheimer's disease. The author has an hindex of 122, co-authored 569 publications receiving 58584 citations. Previous affiliations of Patrick L. McGeer include Laval University & Kyoto University.
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Complement and cytokine gene expression in cultured microglial derived from postmortem human brains.
TL;DR: The number of cases in this study was too small to permit evaluation of microglial response according to the disease state, but the results demonstrate the potential for such studies in the future.
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Molecular and Cellular Characterization of the Membrane Attack Complex, C5b-9, in Alzheimer’s Disease
Scott D. Webster,Lih-Fen Lue,Libuse Brachova,Andrea J. Tenner,Patrick L. McGeer,Kazuhiro Terai,David G. Walker,B Bradt,Neil R. Cooper,Joseph Rogers +9 more
TL;DR: C5b-9 is abundantly present in Alzheimer's disease cortex, associated with neurofibrillary tangle containing neurons, dystrophic neurites within neuritic plaques, and neuropil threads, but is weakly detected, if at all, in nondemented elderly cortex under the same conditions.
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Presence of T-cytotoxic suppressor and leucocyte common antigen positive cells in Alzheimer's disease brain tissue.
TL;DR: Cells expressing leucocyte common antigen (LCA) as well as T-cytotoxic-suppressor (T8) and T-helper-inducer (T4) antigens were detected in significant numbers in the hippocampus and temporal cortex of Alzheimer but not normal brain tissue, indicating a cell mediated immune response in the disease.
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Local neuroinflammation and the progression of Alzheimer’s disease
TL;DR: Much epidemiological and limited clinical evidence suggests that nonsteroidal anti-inflammatory drugs may impede the onset and slow the progression of Alzheimer’s disease, but these drugs strike at the periphery of the inflammatory reaction.
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Distribution of cyclooxygenase-1 and cyclooxygenase-2 mRNAs and proteins in human brain and peripheral organs.
TL;DR: Data suggest a special role for COX-2 in neuronal function in Alzheimer disease and suggest its expression is substantially upregulated in affected areas of AD brain and in infarcted areas of human heart.