P
Patrick L. McGeer
Researcher at University of British Columbia
Publications - 569
Citations - 61292
Patrick L. McGeer is an academic researcher from University of British Columbia. The author has contributed to research in topics: Microglia & Alzheimer's disease. The author has an hindex of 122, co-authored 569 publications receiving 58584 citations. Previous affiliations of Patrick L. McGeer include Laval University & Kyoto University.
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Fibroblast growth factor receptor-1 expression in the cortex and hippocampus in Alzheimer's disease
Kenji Takami,Akinori Matsuo,Akinori Matsuo,Kazuhiro Terai,Douglas G. Walker,Edith G. McGeer,Patrick L. McGeer +6 more
TL;DR: Localization of fibroblast growth receptor (FGFR)-1 immunoreactivity was investigated immunochemically in postmortem brain tissue of Alzheimer's disease and age-matched control cases using a rabbit polyclonal antibody and a mouse monoclonal antibody specific for FGFR-1.
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Differential expression of interferon-γ receptor on human glial cells in vivo and in vitro
TL;DR: The results suggest that the microglial and oligodendrocytic expression levels of IFN-gamma-R are much lower than the astrocytic expression levels in the human CNS in vivo, whereas all three types of glial cells constitutively express IFn-gamMA-R when cultured in vitro.
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Is there a future for vaccination as a treatment for Alzheimer's disease?
TL;DR: The future of vaccination as a therapy for AD will require surmounting the problems of autoimmune reactions generally and autotoxic complement activation specifically.
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High molecular weight basic fibroblast growth factor-like protein is localized to a subpopulation of mesencephalic dopaminergic neurons in the rat brain
Ikuo Tooyama,Douglas G. Walker,Tatsuo Yamada,Kazumitsu Hanai,Hiroshi Kimura,Edith G. McGeer,Patrick L. McGeer +6 more
TL;DR: The results suggest that trophic specialization in subpopulations may occur in all three of these dopaminergic projection systems, i.e. the nigrostriatal, mesolimbic and mesocortical pathways.
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Prolyl endopeptidase is revealed following SILAC analysis to be a novel mediator of human microglial and THP-1 cell neurotoxicity.
Andis Klegeris,Jane Li,Theo K. Bammler,Jinghua Jin,David Zhu,Daniel T. Kashima,Sheng Pan,Sadayuki Hashioka,John Maguire,Patrick L. McGeer,Jing Zhang +10 more
TL;DR: Two specific PEP inhibitors are evaluated for their potential to reduce toxicity of stimulated THP‐1 cell and human microglia supernatants towards SH‐SY5Y cells and found both to be partially protective in a concentration‐dependent manner.