P
Patrick L. McGeer
Researcher at University of British Columbia
Publications - 569
Citations - 61292
Patrick L. McGeer is an academic researcher from University of British Columbia. The author has contributed to research in topics: Microglia & Alzheimer's disease. The author has an hindex of 122, co-authored 569 publications receiving 58584 citations. Previous affiliations of Patrick L. McGeer include Laval University & Kyoto University.
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Anti-rheumatoid arthritic drugs in the treatment of dementia
TL;DR: In this article, a method of treating dementia in human beings which comprises administering to the human being a therapeutic amount of a non-steroidal anti-inflammatory drug (NSAID) which has the ability to inhibit prostaglandin synthesis in the human person.
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Complement Components, but Not Complement Inhibitors, Are Upregulated in Atherosclerotic Plaques
TL;DR: The data indicate that it is primarily the classical, not the alternative pathway, that is activated in plaques and that key inhibitors are not upregulated to defend against this activation.
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Detection of the membrane inhibitor of reactive lysis (CD59) in diseased neurons of Alzheimer brain.
Patrick L. McGeer,Douglas G. Walker,H. Akiyama,T. Kawamata,A.L. Guan,Charles J. Parker,N. Okada,Edith G. McGeer +7 more
TL;DR: First evidence of brain neuronal expression of MIRL and its upregulation in neurons exposed to complement attack is provided, consistent with the previously advanced hypothesis that complement-mediated neuronal injury may play a role in AD.
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Lipid peroxide distribution in brain and the effect of hyperbaric oxygen
TL;DR: In this article, the authors found that the highest levels of lipid peroxide were found in the substantia nigra and spinal cord of the rat brain after exposure to oxygen at high pressure (OHP).
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Coincident expression and distribution of melanotransferrin and transferrin receptor in human brain capillary endothelium
Sylvia Rothenberger,Reinhard Gabathuler,Malcolm L. Kennard,Tatsuo Yamada,Osamu Yasuhara,Patrick L. McGeer,Wilfred A. Jefferies +6 more
TL;DR: The distributions of MTf and the TR were remarkably similar, and quite different from that of Tf, which suggest that MTf may play a role in iron transport within the human brain.