P
Patrick L. McGeer
Researcher at University of British Columbia
Publications - 569
Citations - 61292
Patrick L. McGeer is an academic researcher from University of British Columbia. The author has contributed to research in topics: Microglia & Alzheimer's disease. The author has an hindex of 122, co-authored 569 publications receiving 58584 citations. Previous affiliations of Patrick L. McGeer include Laval University & Kyoto University.
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Amyloid P immunoreactivity precedes C4d deposition on extracellular neurofibrillary tangles.
TL;DR: Researchers studied by immunohistochemistry the relative association of AP, Aβ, and the classical complement protein C4d with eNFTs in Alzheimer’s disease, parkinsonism-dementia complex of Guam (lytico-bodig, LB), and elderly non-Demented cases to investigate the apparent order in which these proteins are deposited.
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Complement activation by islet amyloid polypeptide (IAPP) and α-synuclein 112
Andis Klegeris,Patrick L. McGeer +1 more
TL;DR: Complement activation may contribute to death of insulin-secreting cells in T2DM or to neuronal death in Parkinson disease (PD) and related synucleinopathies where alpha-Syn 112 occurs, which suggests the possibility of anti-inflammatory treatment in these pathologies.
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Inhibitory action of 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide (PK 11195) on some mononuclear phagocyte functions
TL;DR: Powerful ligands of PBRs, such as PK 11195, may be useful inhibitors of selective macrophage functions, retarding both local and systemic inflammation.
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Preconditioning reduces myocardial complement gene expression in vivo.
TL;DR: It is demonstrated that preconditioning significantly decreases reperfusion-induced myocardial complement expression in vivo, and 5-hydroxydecanoate attenuated infarct size reduction elicited by IPC and diazoxide treatment.
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Conversion of tyrosine to catecholamines by cat brain in vivo
TL;DR: This report describes the conversion of L-tyrosine-C14 to catecholamines by cat brain invivo with strong evidence for enzymic conversion and the possibility of nonenzymic hydroxylation under the invitro conditions of the experiment.