P
Patrick L. McGeer
Researcher at University of British Columbia
Publications - 569
Citations - 61292
Patrick L. McGeer is an academic researcher from University of British Columbia. The author has contributed to research in topics: Microglia & Alzheimer's disease. The author has an hindex of 122, co-authored 569 publications receiving 58584 citations. Previous affiliations of Patrick L. McGeer include Laval University & Kyoto University.
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Role of ICAM-1 in persisting inflammation in Parkinson disease and MPTP monkeys.
TL;DR: The presence of ICAM-1-positive reactive astrocytes in Parkinson disease and MPTP-treated monkeys is indicative of a sustained inflammatory process and suggests that antiinflammatory agents may have a place in PD therapy.
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Choline acetyltransferase immunohistochemistry in brains of Alzheimer's disease patients and controls.
TL;DR: The data confirm the reason for the reduction of ChAT as measured biochemically in the neocortex of SDAT cases, and support the cholinergic hypothesis of memory.
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Enhancement of immunoreactivity for NF-κB in the hippocampal formation and cerebral cortex of Alzheimer's disease
TL;DR: The results suggest that enhanced expression of neuronal NF-kappa B occurs in areas affected by AD pathology.
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Distribution of GABA‐T‐Intensive neurons in the hat forebrain and midbrain
TL;DR: The neuronal distribution of 7‐aminobutyric acid (GABA) transaminase (GA BA‐T), the enzyne which metabolizes GABA, has been mapped in rat brain and known non‐GABA neuronal groups are negative for GABA‐T staining under these conditions, reinforcing the hypothesis that GABA neurons are far more inhibitory than other neurons.
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Demonstration of a pallido-nigral projection innervating dopaminergic neurons.
TL;DR: Afferents to the substantia nigra from the neostriatum and globus pallidus were studied in the rat by means of the autoradiographic tracing technique and degeneration of dopaminergic cells in the substantium nigra was induced by intraventricular injection of 6‐hydroxydopamine 72 hours before sacrifice.