P
Patrick L. McGeer
Researcher at University of British Columbia
Publications - 569
Citations - 61292
Patrick L. McGeer is an academic researcher from University of British Columbia. The author has contributed to research in topics: Microglia & Alzheimer's disease. The author has an hindex of 122, co-authored 569 publications receiving 58584 citations. Previous affiliations of Patrick L. McGeer include Laval University & Kyoto University.
Papers
More filters
Journal ArticleDOI
Influence of noncholinergic drugs on rat striatal acetylcholine levels
TL;DR: Rat striatal acetylcholine levels were measured in rats following the administration of drugs that primarily affect dopamine metabolism, and the increase following drugs that enhance dopamine or stimulate its receptors is consistent with a direct inhibitory action of dopamine on cholinergic striatal interneurons.
Journal ArticleDOI
Inflammation, Antiinflammatory Agents, and Alzheimer's Disease: The Last 22 Years.
TL;DR: This article showed that the longer the NSAIDs were used prior to clinical diagnosis, the greater the sparing effect of non-steroidal anti-inflammatory drugs (NSAIDs) in AD.
Journal ArticleDOI
The efferent projections of the rat lateral habenular nucleus revealed by the PHA-L anterograde tracing method.
TL;DR: The efferent connections of the rat lateral habenular nucleus were demonstrated using anterograde transport of the lectin Phaseolus vulgaris leucoagglutinin (PHA-L) and several new findings were revealed.
Journal ArticleDOI
Major histocompatibility complex antigen expression on rat microglia following epidural kainic acid lesions.
TL;DR: Vigorous expression of major histocompatibility complex (MHC) class I and class I surface glycoproteins was observed on reactive microglia but not on astrocytes in the rat brain following lesions induced by epidural kainic acid (KA).
Journal ArticleDOI
Temporal changes in amine synthesizing enzymes of rat extrapyramidal structures after hemitransections or 6-hydroxydopamine administration.
TL;DR: The data support the hypotheses that a descending gabaminergic path exists with nerve endings in the nigra, and that striatal cholinergic neurons are predominantly short axon and intra-striatal in character.