P
Patrick L. McGeer
Researcher at University of British Columbia
Publications - 569
Citations - 61292
Patrick L. McGeer is an academic researcher from University of British Columbia. The author has contributed to research in topics: Microglia & Alzheimer's disease. The author has an hindex of 122, co-authored 569 publications receiving 58584 citations. Previous affiliations of Patrick L. McGeer include Laval University & Kyoto University.
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Journal ArticleDOI
A case of adult-onset dementia with argyrophilic grains.
S. Itagaki,Patrick L. McGeer,H. Akiyama,B. L. Beattie,Douglas G. Walker,G. R. W. Moore,Edith G. McGeer +6 more
TL;DR: Although the case was clinically indistinguishable from Alzheimer's disease, plaque and tangle pathological findings were absent and cortical changes of the type described by Braak and Braak are confirmed and additional data on subcortical changes in this case is provided.
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Modulation of human microglia and THP-1 cell toxicity by cytokines endogenous to the nervous system
TL;DR: Toxicity induced by the various stimulatory combinations tested suggested that antagonists of cytokine receptors, as well as inhibitors of their intracellular pathways may be effective anti-inflammatory agents.
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Subcellular localization of tyrosine hydroxylase in beef caudate nucleus
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Autotoxicity and Alzheimer disease.
TL;DR: The fact that such a reaction can be mounted by brain, an organ frequently described as being immunologically privileged, suggests that a reevaluation is required of the dimensions of the innate immune system, including how it operates at the tissue level.
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Occurrence of HLA-DR reactive microglia in Alzheimer's disease.
TL;DR: Sensitive immunohistochemical procedures were used to detect reactive microglia (macrophages) positive for HLA-DR in postmortem tissue in cases of Alzheimer’s disease, finding them concentrated in areas of senile plaque formation.