P
Patrick L. McGeer
Researcher at University of British Columbia
Publications - 569
Citations - 61292
Patrick L. McGeer is an academic researcher from University of British Columbia. The author has contributed to research in topics: Microglia & Alzheimer's disease. The author has an hindex of 122, co-authored 569 publications receiving 58584 citations. Previous affiliations of Patrick L. McGeer include Laval University & Kyoto University.
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Journal ArticleDOI
Ionotropic and metabotropic neurotransmission
John C. Eccles,Patrick L. McGeer +1 more
TL;DR: It is suggested that the diversities of postsynaptic actions can be resolved into two distinct classes, named ionotropic and metabotropic, as has been fully described in the current book.
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Acetylcholinesterase fibers and the development of senile plaques.
TL;DR: In Alzheimer's disease tissue, many degenerating neurons in the basal forebrain were detected by the AChE histochemical stain, along with pathological alterations in the proximal axons en route to their cortical terminal fields.
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Descending projections of the basal forebrain in the rat demonstrated by the anterograde neural tracer Phaseolus vulgaris leucoagglutinin (PHA-L)
Hidekazu Tomimoto,Hidekazu Tomimoto,Hisaki Kamo,Hisaki Kamo,Masakuni Kameyama,Masakuni Kameyama,Patrick L. McGeer,Patrick L. McGeer,Hiroshi Kimura,Hiroshi Kimura +9 more
TL;DR: Descending pathways from the mediobasal forebrain were studied in the rat by injecting anterograde axonal tracer Phaseolus vulgaris leucoagglutinin into the substantia innominata and diagonal band of Broca.
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Inhibition of human astrocyte and microglia neurotoxicity by calcium channel blockers.
TL;DR: It is suggested that L-type CCBs attenuate IFN-γ-induced neurotoxicity of human astrocytes through inhibition of the STAT3 signaling pathway and might be a useful treatment option for a broad spectrum of neurodegenerative diseases, including Alzheimer disease.
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Effect of locally applied hemicholinium on the acetylcholine content of the caudate nucleus.
TL;DR: The effects of HC-3, injected directly into the caudate nucleus of the rat, on the acetyl choline content of the nucleus, and on its ability to convert radioactive choline to acetylcholine are observed.