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Patrick R. Hof

Researcher at Icahn School of Medicine at Mount Sinai

Publications -  834
Citations -  73115

Patrick R. Hof is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Neocortex & Alzheimer's disease. The author has an hindex of 130, co-authored 796 publications receiving 64987 citations. Previous affiliations of Patrick R. Hof include Albert Einstein College of Medicine & National Institutes of Health.

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Molecular evolution of the cytochrome c oxidase subunit 5A gene in primates

TL;DR: Examination of catarrhine brain samples by immunohistochemistry characterizes for the first time COX5A protein distribution in the primate neocortex, and suggests that the protein is most abundant in the mitochondria of large-size projection neurons.
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Comparative organization of the claustrum: what does structure tell us about function?

TL;DR: The presence of discontinuities in the structure of the claustrum, present but minimal in some primates, but dramatically clear in cetaceans, argues against the proposed mechanisms of intraclaustral processing of information.
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Morphomolecular neuronal phenotypes in the neocortex reflect phylogenetic relationships among certain mammalian orders

TL;DR: An overview of the morphologic characteristics and distribution of three calcium-binding proteins, parvalbumin, calbindin, and calretinin,and of a component of the neuronal cytoskeleton, nonphosphorylated neurofilament protein in the neocortex of various species, representative of the major subdivisions of mammals.
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Distribution of neurofilament protein and calcium-binding proteins parvalbumin, calbindin, and calretinin in the canine hippocampus.

TL;DR: Comparison of the staining patterns observed in the dog hippocampus with those in human, macaque monkeys and rats revealed that although there are some subregional differences among these taxa, the dog may constitute a valuable large animal model for the study of certain neurological conditions that affect humans, in spite of the phylogenetic distance between carnivores and primates.
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Hick-Hyman Law is Mediated by the Cognitive Control Network in the Brain.

TL;DR: The findings indicate that the CCN serves as a core entity underlying the Hick-Hyman law by coordinating uncertainty representation and response generation in the brain.