P
Patrick R. Hof
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 834
Citations - 73115
Patrick R. Hof is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Neocortex & Alzheimer's disease. The author has an hindex of 130, co-authored 796 publications receiving 64987 citations. Previous affiliations of Patrick R. Hof include Albert Einstein College of Medicine & National Institutes of Health.
Papers
More filters
Journal ArticleDOI
A neuronal aging pattern unique to humans and common chimpanzees
Emmanuel Gilissen,Emmanuel Gilissen,Emmanuel Gilissen,Karelle Leroy,Zehra Yilmaz,Eniko Veronika Kovari,Constantin Bouras,Alain Boom,Luc Poncelet,Joseph M. Erwin,Chet C. Sherwood,Patrick R. Hof,Jean Pierre Brion +12 more
TL;DR: The findings suggest that when compared with other primates, Purkinje cells in chimpanzees and humans might share a common aging pattern that involves mechanisms for neuroprotection when considering animal models of aging.
Journal ArticleDOI
Policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al.†
Andrea C. Gore,Jacques Balthazart,Daniel D. Bikle,David O. Carpenter,David Crews,Paul Czernichow,Evanthia Diamanti-Kandarakis,Robert M. Dores,David R. Grattan,Patrick R. Hof,Anthony N. Hollenberg,Carol A. Lange,Adrian V. Lee,Jon E. Levine,Robert P. Millar,Randy J. Nelson,Miquel Porta,Merrily Poth,Deborah M. Power,Gail S. Prins,E. C. Ridgway,Emilie F. Rissman,Johannes A. Romijn,Paul E. Sawchenko,Peter D. Sly,Olle Söder,Hugh S. Taylor,Manuel Tena-Sempere,Hubert Vaudry,Kim Wallen,Zuoxin Wang,Leonard Wartofsky,Cheryl S. Watson +32 more
TL;DR: The present work presents a meta-analysis of six murine models of central giant cell reprograming that has shown clear patterns of action towards EMT and aims to clarify these patterns and identify the “driving forces” that cause cell death.
Journal ArticleDOI
Targeted disruption of the dopamine D2 and D3 receptor genes leads to different alterations in the expression of striatal calbindin-D28k
TL;DR: The topography of the decreased density of striatal calbindin immunorectivity in D(3) mutants suggests a role for D( 3) receptors in supporting the expression ofstriatal cal bindin.
Journal ArticleDOI
Early-life stress and neurometabolites of the hippocampus.
Jeremy D. Coplan,Sanjay J. Mathew,Chadi G. Abdallah,Xiangling Mao,John G. Kral,Eric L. Smith,Leonard A. Rosenblum,Tarique D. Perera,Andrew J. Dwork,Patrick R. Hof,Jack M. Gorman,Dikoma C. Shungu +11 more
TL;DR: Current data indicate that decreased left MTL NAA/Cho may reflect low neuronal viability of the hippocampus following early life stress in VFD-reared versus normally-rearing subjects and correlative neurohistological studies of hippocampus are warranted.
Journal ArticleDOI
Investigation of dopamine content, synthesis, and release in the rabbit retina in vitro. I: Effects of dopamine precursors, reserpine, amphetamine, and L-DOPA decarboxylase and monoamine oxidase inhibitors
TL;DR: It is demonstrated that the LC‐EC technique may be used to investigate the modulation of the synthesis and release of retinal DA in vitro, without the prior uptake of radiolabelled transmitter.