Patrick R. Hof

TL;DR: The heterogeneous white matter composition found in large brains reflects a metabolically constrained trade-off that reduces both volume and conduction time, and in select sets of communicating fibers, large brains reduce transmission delays and metabolic firing costs at the expense of increased volume.

TL;DR: Results document that, although the aged primate PFC is vulnerable in the absence of factors such as circulating estrogens, it remains responsive to long-term cyclic 17β-estradiol treatment, and that increased dendritic spine density and altered spine morphology may contribute to the cognitive benefits of such treatment.

TL;DR: Based on a relatively small sample of post-mortem brains from patients with autism and controls, the results of the present study may provide important insight about the cellular basis of abnormalities in face perception in autism.

TL;DR: Data suggest that in some cases with visual variants of Alzheimer's disease, the neurological symptomatology may be related to the loss of certain components of the cortical visual pathways, as reflected by the particular distribution of the neuropathological markers of the disease.

TL;DR: Testing the hypothesis that the projections from the infralimbic area of the medial prefrontal cortex to the basolateral nucleus of the amygdala, a pathway relevant to stress-related mental illnesses like depression and post-traumatic stress disorder, would have a unique pattern of remodeling in response to chronic stress found this pathway to be particularly resilient against the effects of stress.