P
Patrick R. Hof
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 834
Citations - 73115
Patrick R. Hof is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Neocortex & Alzheimer's disease. The author has an hindex of 130, co-authored 796 publications receiving 64987 citations. Previous affiliations of Patrick R. Hof include Albert Einstein College of Medicine & National Institutes of Health.
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Journal ArticleDOI
Stereological analysis of neuropil threads in the hippocampal formation: relationships with Alzheimer's disease neuronal pathology and cognition
Panteleimon Giannakopoulos,A. Von Gunten,E. Kövari,Gabriel Gold,François Herrmann,Patrick R. Hof,Constantin Bouras +6 more
TL;DR: The data reveal that NT formation in hippocampal subdivisions and entorhinal cortex accompanies AD neuronal pathology in early stages of the degenerative process, yet its rate may decrease in severe dementia, yet in terms of clinicopathological correlations, NT length in the hippocampal formation does not represent an independent marker of dementia severity.
Journal ArticleDOI
Stereological assessment of the dorsal anterior cingulate cortex in schizophrenia: absence of changes in neuronal and glial densities
TL;DR: M. Höistad, H. Heinsen, B. Wicinski, C. Schmitz and P. R. Hof (2013) Neuropathology and Applied Neurobiology39, 348–361.
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Evaluation of cerebrospinal fluid phosphorylated tau231 as a biomarker in the differential diagnosis of Alzheimer's disease and vascular dementia.
Spomenka Kiđemet-Piskač,Mirjana Babić Leko,Antonela Blažeković,Lea Langer Horvat,Nataša Klepac,Zdenko Sonicki,Danijela Kolenc,Patrick R. Hof,Marina Boban,Ninoslav Mimica,Fran Borovečki,Goran Šimić +11 more
TL;DR: The diagnosis of either Alzheimer's disease (AD) or vascular dementia (VaD) is still largely based on clinical guidelines and exclusion of other diseases that may lead to dementia.
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Ultrastructural analyses in the hippocampus CA1 field in Shank3-deficient mice
Neha Uppal,Rishi Puri,Frank J. Yuk,William G.M. Janssen,Ozlem Bozdagi-Gunal,Hala Harony-Nicolas,Dara L. Dickstein,Joseph D. Buxbaum,Patrick R. Hof +8 more
TL;DR: Although this finding represents preliminary evidence for ultrastructural alterations, it suggests that while major structural changes seem to be compensated for in Shank3-deficient mice, more subtle morphological alterations, affecting synaptic structure, may take place in an age-dependent manner.
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Changes in Lipidome Composition during Brain Development in Humans, Chimpanzees, and Macaque Monkeys.
Qian Li,Katarzyna Bozek,Chuan Xu,Yanan Guo,Jing Sun,Svante Pääbo,Chet C. Sherwood,Patrick R. Hof,John J. Ely,Yan Li,Lothar Willmitzer,Patrick Giavalisco,Philipp Khaitovich +12 more
TL;DR: A comprehensive mass spectrometry-based analysis of lipidome composition in the prefrontal cortex of 40 humans, chimpanzees, and 40 rhesus monkeys over postnatal development and adulthood finds human-specific lipidome differences persist over most of the lifespan and reach their peak from 20 to 35 years of age, when compared with chimpanzee-specific ones.