P
Patrick R. Hof
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 834
Citations - 73115
Patrick R. Hof is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Neocortex & Alzheimer's disease. The author has an hindex of 130, co-authored 796 publications receiving 64987 citations. Previous affiliations of Patrick R. Hof include Albert Einstein College of Medicine & National Institutes of Health.
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Journal ArticleDOI
Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease.
Panteleimon Giannakopoulos,François Herrmann,Thierry Bussière,Thierry Bussière,Constantin Bouras,Constantin Bouras,Eniko Veronika Kovari,Daniel P. Perl,John H. Morrison,Gabriel Gold,Patrick R. Hof +10 more
TL;DR: New stereologic data indicate that neuronal pathology in hippocampal formation and frontal cortex closely reflects the progression of cognitive deficits in brain aging and AD, and demonstrate that amyloid volume has no additional predictive value, in terms of clinicopathologic correlations, beyond its interaction with NFT.
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The anterior cingulate cortex. The evolution of an interface between emotion and cognition.
TL;DR: It is proposed that the anterior cingulate cortex is a specialization of neocortex rather than a more primitive stage of cortical evolution, and thus are a recent evolutionary specialization probably related to these functions central to intelligent behavior.
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Stress-Induced Alterations in Prefrontal Cortical Dendritic Morphology Predict Selective Impairments in Perceptual Attentional Set-Shifting
Conor Liston,Melinda M. Miller,Deena Goldwater,Jason J. Radley,Anne B. Rocher,Patrick R. Hof,John H. Morrison,Bruce S. McEwen +7 more
TL;DR: This study provides the first direct evidence that dendritic remodeling in the prefrontal cortex may underlie the functional deficits in attentional control that are symptomatic of stress-related mental illnesses.
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Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder
Michael J. Gandal,Pan Zhang,Evi Hadjimichael,Rebecca L. Walker,Chao Chen,Shuang Liu,Hyejung Won,Harm van Bakel,Merina Varghese,Yongjun Wang,Annie W. Shieh,Jillian R. Haney,Sepideh Parhami,Judson Belmont,Minsoo Kim,Patricia Moran Losada,Zenab Khan,Justyna Mleczko,Yan Xia,Yan Xia,Rujia Dai,Rujia Dai,Daifeng Wang,Yucheng T. Yang,Min Xu,Kenneth N. Fish,Patrick R. Hof,Jonathan Warrell,Dominic Fitzgerald,Kevin P. White,Andrew E. Jaffe,Mette A. Peters,Mark Gerstein,Chunyu Liu,Chunyu Liu,Chunyu Liu,Lilia M. Iakoucheva,Dalila Pinto,Daniel H. Geschwind +38 more
TL;DR: This work integrated genotypes and RNA sequencing in brain samples from 1695 individuals with autism spectrum disorder, schizophrenia, and bipolar disorder, as well as controls to identify causal drivers and define a mechanistic basis for the composite activity of genetic risk variants.
Journal ArticleDOI
White matter changes in schizophrenia: evidence for myelin-related dysfunction.
Kenneth L. Davis,Daniel G. Stewart,Joseph I. Friedman,Monte S. Buchsbaum,Philip D. Harvey,Patrick R. Hof,Joseph D. Buxbaum,Vahram Haroutunian +7 more
TL;DR: Support for the hypothesis that oligodendroglial dysfunction and even death, with subsequent abnormalities in myelin maintenance and repair, contribute to the schizophrenic syndrome is supported.