P
Patrick R. Hof
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 834
Citations - 73115
Patrick R. Hof is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Neocortex & Alzheimer's disease. The author has an hindex of 130, co-authored 796 publications receiving 64987 citations. Previous affiliations of Patrick R. Hof include Albert Einstein College of Medicine & National Institutes of Health.
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Brain and blood biomarkers of tauopathy and neuronal injury in humans and rats with neurobehavioral syndromes following blast exposure
Dara L. Dickstein,Rita De Gasperi,Rita De Gasperi,Miguel A. Gama Sosa,Miguel A. Gama Sosa,Georgina Perez-Garcia,Georgina Perez-Garcia,Jennifer A. Short,Heidi Sosa,Heidi Sosa,Gissel M. Perez,Anna E. Tschiffely,Kristen Dams-O'Connor,Mariel Y. Pullman,Karin Knesaurek,Andrew K. Knutsen,Dzung L. Pham,Lale Soleimani,Barry D. Jordan,Wayne A. Gordon,Bradley N. Delman,Gleb P. Shumyatsky,Pashtun-Poh Shahim,Steven T. DeKosky,James R. Stone,Elaine R. Peskind,Kaj Blennow,Kaj Blennow,Henrik Zetterberg,Steven A. Chance,Mario Torso,Lale Kostakoglu,Mary Sano,Mary Sano,Patrick R. Hof,Stephen T. Ahlers,Sam Gandy,Gregory A. Elder +37 more
TL;DR: In this article, the authors identified biomarker signatures in rats exposed to repetitive low-level blast that develop chronic anxiety-related traits and in human veterans exposed to IED blasts in theater with behavioral, cognitive, and/or memory complaints.
Journal ArticleDOI
Early Alzheimer-type lesions in cognitively normal subjects.
Stergios Tsartsalis,Aikaterini Xekardaki,Patrick R. Hof,Eniko Veronika Kovari,Constantin Bouras +4 more
TL;DR: Evidence is provided that neurofibrillary tangles appear earlier than amyloid plaques during normal brain aging, lending evidence to the fact that the role of amyloids in promoting tau deposition cannot be excluded in some cases but may not represent the sole mechanism of disease induction and progression.
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Parvalbumin-containing interneurons in rat hippocampus have an AMPA receptor profile suggestive of vulnerability to excitotoxicity
TL;DR: A subset of parvalbumin (PV)-containing interneurons in the hippocampus and neocortex was found that was notable for its intense GluR3 immunoreactivity and lack of GLUR2 Immunoreactivity, likely to make these interneuronons selectively vulnerable to excitotoxicity.
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The Relationship between Intelligence and Anxiety: An Association with Subcortical White Matter Metabolism
Jeremy D. Coplan,Sarah G Hodulik,Sanjay J. Mathew,Xiangling Mao,Patrick R. Hof,Jack M. Gorman,Dikoma C. Shungu +6 more
TL;DR: The collective data suggest that both worry and intelligence are characterized by depletion of metabolic substrate in the subcortical white matter and that intelligence may have co-evolved with worry in humans.
Journal ArticleDOI
Neuroanatomy of the killer whale (Orcinus orca) from magnetic resonance images
Lori Marino,Lori Marino,Chet C. Sherwood,Bradley N. Delman,Cheuk Y. Tang,Thomas P. Naidich,Patrick R. Hof +6 more
TL;DR: The first series of MRI-based anatomically labeled sectioned images of the brain of the killer whale (Orcinus orca) are presented, showing an exceptional degree of cortical elaboration in the insular cortex, temporal operculum, and the cortical limbic lobe.