Patrick R. Hof

TL;DR: It is proposed that the developmental period of heightened childhood neuronal plasticity is characterized by more dynamic patterns of gene expression in the cerebral cortex compared to adulthood when the brain is less plastic.

TL;DR: Evidence for links between the neurochemical phenotype of a given neuron and its relative vulnerability or resistance to the degenerative process are presented in order to correlate the distribution of cellular pathologic changes, neurochemical characteristics related to vulnerability, and affected cortical circuits.

TL;DR: This research will identify which neural features are likely to generalize across species, and which are unlikely to be broadly conserved, and suggest causal relationships between genes, development, adult anatomy, physiology, and, ultimately, behavior.

TL;DR: The loadings on PCs indicated that the brain structure of great apes differs among taxa mostly in the relative sizes of the striatum, cerebellum, and hippocampus, suggesting possible functional differences amongTaxa in terms of neural adaptations for ecological and locomotor capacities.

TL;DR: While differences in the cholinergic system exist among primate species, such changes appear to involve mostly axon collateral terminations within the neocortex and, with the exception of the relatively small group of Ch4 cell group of the subputaminal subdivision of the nbM, are not accompanied by a significant extra-allometric increase in the overall number of subcortical neurons that provide that innervation.