P
Patrick R. Hof
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 834
Citations - 73115
Patrick R. Hof is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Neocortex & Alzheimer's disease. The author has an hindex of 130, co-authored 796 publications receiving 64987 citations. Previous affiliations of Patrick R. Hof include Albert Einstein College of Medicine & National Institutes of Health.
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Journal ArticleDOI
Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold.
Andreas M. Grabrucker,Andreas M. Grabrucker,Michael J. Schmeisser,Patrick T Udvardi,Magali H. Arons,Michael Schoen,Nathaniel S. Woodling,Katrin I. Andreasson,Patrick R. Hof,Joseph D. Buxbaum,Craig C. Garner,Tobias M. Boeckers +11 more
TL;DR: It is concluded that sequestration of Zn2+ ions by Aβ significantly contributes to changes in ProSAP2/Shank3 platforms, which lead to less consolidated synapses reflected by a decrease in Shank1 protein levels at the PSD and decreased synapse density in hippocampal neurons.
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Cellular and synaptic distribution of NR2A and NR2B in macaque monkey and rat hippocampus as visualized with subunit-specific monoclonal antibodies.
William G.M. Janssen,Prabakhar Vissavajjhala,Ginelle Andrews,Thomas M. Moran,Patrick R. Hof,John H. Morrison +5 more
TL;DR: The confocal and ultrastructural data suggest that whereas NR1, NR2A, and NR2B are essentially uniformly colocalized in hippocampal projection neurons, there is extensive heterogeneity at the synaptic level that would lead to multiple functional classes of NMDA receptor-mediated synapses, and extensive capacity for plasticity at the synapse.
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Decreased pyramidal neuron size in Brodmann areas 44 and 45 in patients with autism
Sarah Jacot-Descombes,Neha Uppal,Bridget Wicinski,Micaela Santos,James Schmeidler,Panteleimon Giannakopoulos,Helmut Heinsen,Christoph Schmitz,Patrick R. Hof +8 more
TL;DR: The results of this study provide further evidence for the possible involvement of the mirror neuron system, as well as impairment of neuronal networks relevant to communication and social behaviors, in this disorder.
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Involvement of the anterior cingulate and frontoinsular cortices in rapid processing of salient facial emotional information.
Jin Fan,Jin Fan,Xiaosi Gu,Xun Liu,Xun Liu,Kevin G. Guise,Yunsoo Park,Laura Martin,Ashley de Marchena,Cheuk Y. Tang,Michael J. Minzenberg,Patrick R. Hof +11 more
TL;DR: The pregenual ACC and the FI, together with other regions, such as the amygdala, were preferentially activated in response to fearful face priming, suggesting that these regions are involved in the rapid processing of salient facial emotional information.
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Pathological τ proteins in postencephalitic parkinsonism: Comparison with Alzheimer's disease and other neurodegenerative disorders
Valérie Buée-Scherrer,Luc Buée,Bátrice Leveugle,Bátrice Leveugle,Daniel P. Perl,Patrick Vermersch,Patrick R. Hof,André Delacourte +7 more
TL;DR: By immunobloting, a τ protein triplet similar to the one seen in Alzheimer's disease was observed, this biochemical approach allows for the definition of postencephalitic parkinsonism from certain neurodegenerative disorders such as progressive supranuclear palsy and corticobasal degeneration.