P
Patrick R. Hof
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 834
Citations - 73115
Patrick R. Hof is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Neocortex & Alzheimer's disease. The author has an hindex of 130, co-authored 796 publications receiving 64987 citations. Previous affiliations of Patrick R. Hof include Albert Einstein College of Medicine & National Institutes of Health.
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Journal ArticleDOI
Cetaceans Have Complex Brains for Complex Cognition
Lori Marino,Richard C. Connor,R. Ewan Fordyce,Louis M. Herman,Patrick R. Hof,Louis Lefebvre,David Lusseau,Brenda McCowan,Esther A. Nimchinsky,Adam A. Pack,Luke Rendell,Joy S. Reidenberg,Diana Reiss,Diana Reiss,Mark D. Uhen,Estel Van der Gucht,Hal Whitehead +16 more
TL;DR: A group of eminent cetacean researchers respond to headlines charging that dolphins might be "flippin' idiots" by concluding that the large brain of cets evolved to support complex cognitive abilities.
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Regional Distribution of Neurofibrillary Tangles and Senile Plaques in the Cerebral Cortex of Elderly Patients: A Quantitative Evaluation of a One-Year Autopsy Population from a Geriatric Hospital
Constantin Bouras,Patrick R. Hof,Panteleimon Giannakopoulos,Jean-Pierre Michel,John H. Morrison +4 more
TL;DR: In this paper, the authors performed a quantitative neuropathologic evaluation of a large series of elderly patients representing the entire autopsy population for the year 1989 from a geriatric hospital in order to investigate the distribution of lesions associated with aging and with the earliest symptoms of senile dementia.
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Recommendations for straightforward and rigorous methods of counting neurons based on a computer simulation approach.
Christoph Schmitz,Patrick R. Hof +1 more
TL;DR: The present results may constitute a new set of recommendations for the rigorous usage of design-based stereology, and strongly recommend counting considerably more neurons than is currently done in the literature when estimating total neuronal numbers using design- based stereology.
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Neurofilament protein defines regional patterns of cortical organization in the macaque monkey visual system: a quantitative immunohistochemical analysis
Patrick R. Hof,John H. Morrison +1 more
TL;DR: It is possible that neurofilament protein is crucial for the unique capacity of certain subsets of neurons to perform the highly precise mapping functions of the monkey visual system.
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Dendritic BC200 RNA in aging and in Alzheimer's disease.
TL;DR: Small untranslated BC1 and BC200 RNAs are translational regulators that are selectively targeted to somatodendritic domains of neurons, and up-regulation in AD was specific to brain areas that are involved in the disease.