P
Patrick R. Hof
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 834
Citations - 73115
Patrick R. Hof is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Neocortex & Alzheimer's disease. The author has an hindex of 130, co-authored 796 publications receiving 64987 citations. Previous affiliations of Patrick R. Hof include Albert Einstein College of Medicine & National Institutes of Health.
Papers
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Journal ArticleDOI
High-throughput RNA sequencing reveals structural differences of orthologous brain-expressed genes between western lowland gorillas and humans
Leonard Lipovich,Zhuo Cheng Hou,Hui Jia,Christopher Sinkler,Michael R. McGowen,Kirstin N. Sterner,Amy Weckle,Amara B. Sugalski,Lenore Pipes,Domenico L. Gatti,Christopher E. Mason,Chet C. Sherwood,Patrick R. Hof,Christopher W. Kuzawa,Lawrence I. Grossman,Morris Goodman,Derek E. Wildman,Derek E. Wildman +17 more
TL;DR: The gorilla neocortical transcriptome comprises an empirical, not homology‐ or prediction‐driven, resource for orthologous gene comparisons between human and gorilla, pointing to candidate genes that may contribute to the traits distinguishing humans from other closely related great apes.
Posted ContentDOI
Adolescent frontal top-down neurons receive heightened local drive to establish adult attentional behavior in mice
Elisa M. Nabel,Yury Garkun,Hiroyuki Koike,Masato Sadahiro,Ana Liang,Kevin J. Norman,Giulia Taccheri,Michael P. Demars,Susanna Im,Keaven Caro,Sarah A. Lopez,Julia Bateh,Patrick R. Hof,Roger L. Clem,Hirofumi Morishita +14 more
TL;DR: Ad adolescence is uncovered as a developmental stage when frontal top-down neurons projecting from the anterior cingulate to visual cortex are highly functionally integrated into local excitatory circuitry and have heightened activity compared to adulthood.
Book ChapterDOI
The Minicolumn in Comparative Context
TL;DR: The preliminary analysis indicates that minicolumn width increases with increasing brain mass among anthropoid primates, but this relationship is not constant when applied to other taxonomic orders, highlighting the need for further comparative analyses of minicol Autumn structure and their ecological, behavioral, and cognitive correlates.
Journal ArticleDOI
Variable temporoinsular cortex neuroanatomy in primates suggests a bottleneck effect in eastern gorillas
Sarah K. Barks,Amy L. Bauernfeind,Christopher J. Bonar,Michael R. Cranfield,Alexandra A. de Sousa,Joseph M. Erwin,William D. Hopkins,Albert H. Lewandowski,Antoine Mudakikwa,Kimberley A. Phillips,Mary Ann Raghanti,Cheryl D. Stimpson,Patrick R. Hof,Karl Zilles,Karl Zilles,Chet C. Sherwood +15 more
TL;DR: It is suggested that fusion between temporal and insular cortex is an example of a relatively rare neuroanatomical feature that has become more common in eastern gorillas, possibly as the result of a population bottleneck effect.
Book ChapterDOI
Menopause and Reproductive Senescence in Comparative Context
Joseph M. Erwin,Patrick R. Hof +1 more
TL;DR: This chapter introduces a range of issues and reviews studies of female primate reproductive senescence and menopause, and includes emphases ranging from comparative medicine and primate models of human health to zoology and human evolution.