P
Patrick R. Hof
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 834
Citations - 73115
Patrick R. Hof is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Neocortex & Alzheimer's disease. The author has an hindex of 130, co-authored 796 publications receiving 64987 citations. Previous affiliations of Patrick R. Hof include Albert Einstein College of Medicine & National Institutes of Health.
Papers
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Journal ArticleDOI
Organization and Evolution of Brain Lipidome Revealed by Large-Scale Analysis of Human, Chimpanzee, Macaque, and Mouse Tissues
Katarzyna Bozek,Katarzyna Bozek,Yuning Wei,Zheng Yan,Xiling Liu,Jieyi Xiong,Masahiro Sugimoto,Masaru Tomita,Svante Pääbo,Chet C. Sherwood,Patrick R. Hof,John J. Ely,Yan Li,Dirk Steinhauser,Lothar Willmitzer,Patrick Giavalisco,Philipp Khaitovich +16 more
TL;DR: A large-scale mass spectrometry-based analysis of the lipid composition of three brain regions as well as kidney and skeletal muscle of humans, chimpanzees, rhesus macaques, and mice provides the first insights into the role of lipids in human brain evolution.
Journal ArticleDOI
Cortical microinfarcts and demyelination affect cognition in cases at high risk for dementia.
Eniko Veronika Kovari,Gabriel Gold,François Herrmann,Alessandra Canuto,Patrick R. Hof,Constantin Bouras,Panteleimon Giannakopoulos +6 more
TL;DR: Cortical microinfarcts and, to a lesser degree, periventricular demyelination contribute to the cognitive decline in individuals at high risk for dementia.
Book ChapterDOI
Life and death of neurons in the aging cerebral cortex.
John H. Morrison,Patrick R. Hof +1 more
TL;DR: Estrogen levels affect spine density on pyramidal neurons in the prefrontal cortex; these neurons may provide many of the same circuits implicated in AAMI and suggest that the synaptic alterations prevalent in normal aging may be responsive to therapy.
Journal ArticleDOI
Mice Lacking Dopamine D2 and D3 Receptors Exhibit Differential Activation of Prefrontal Cortical Neurons during Tasks Requiring Attention
TL;DR: D dopamine differentially modulates prefrontal cortical activity during tasks requiring attention depending upon the type of D2-like receptor that is activated, indicating that response accuracy in the cognitive test correlates with the magnitude of prefrontal cortical activation regardless of which test phases revealed different performances.
Journal ArticleDOI
Differential vulnerability of oculomotor, facial, and hypoglossal nuclei in G86R superoxide dismutase transgenic mice.
Esther A. Nimchinsky,Warren G. Young,Glendy Yeung,Ravi A. Shah,Jon W. Gordon,Floyd E. Bloom,John H. Morrison,Patrick R. Hof +7 more
TL;DR: The relatively moderate and late involvement of the hypoglossal nucleus indicates that, although the general patterns of neuronal pathology match closely those seen in ALS patients, some differences exist in this transgenic model compared with the progression of the disease in humans.