Patrick R. Hof

TL;DR: The loss of these interneurons in AD may have substantial functional repercussions on local inhibitory processes in the hippocampus, and comparable PV- and CR-ir neuron losses were observed in the dentate gyrus of postmortem brain specimens obtained from patients with AD.

TL;DR: The findings support the conclusion that leftward asymmetry of Wernicke's area originated prior to the appearance of modern human language and before the authors' divergence from the last common ancestor and provide the first evidence of covariance between asymmetric of anterior and posterior cortical regions that in humans are important to language and other higher order cognitive functions.

TL;DR: It is demonstrated that the enhanced kinase activity resulting from the most frequent G2019S mutation in LRRK2 is the key to this impairment in SV trafficking selectively in MB neurons but not cortical neurons caused by two PARK genes.

TL;DR: The data provide a staging of cognitive, structural/ultrastructural, and neuropathological markers in the STZ-icv rat model that in many aspects seems to be generally comparable to stages seen in human sAD.

TL;DR: In comparisons of unmedicated schizophrenia patients with normal volunteers, relative metabolic increases are apparent in white matter in patients with schizophrenia as well as decreases in gray matter.