P
Patrick R. Hof
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 834
Citations - 73115
Patrick R. Hof is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Neocortex & Alzheimer's disease. The author has an hindex of 130, co-authored 796 publications receiving 64987 citations. Previous affiliations of Patrick R. Hof include Albert Einstein College of Medicine & National Institutes of Health.
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Journal ArticleDOI
Abnormal autonomic and associated brain activities during rest in autism spectrum disorder
Tehila Eilam-Stock,Tehila Eilam-Stock,Tehila Eilam-Stock,Pengfei Xu,Miao Cao,Xiaosi Gu,Xiaosi Gu,Nicholas T. Van Dam,Nicholas T. Van Dam,Evdokia Anagnostou,Alexander Kolevzon,Latha Soorya,Yunsoo Park,Michael Siller,Yong He,Patrick R. Hof,Jin Fan +16 more
TL;DR: The relationship between non-specific skin conductance response, an objective index of sympathetic neural activity, and brain fluctuations during rest in high-functioning adults with autism spectrum disorder relative to neurotypical controls is investigated.
Journal ArticleDOI
Humoral immunity in brain aging and Alzheimer's disease.
Constantin Bouras,Beat M. Riederer,Eniko Veronika Kovari,Patrick R. Hof,Panteleimon Giannakopoulos +4 more
TL;DR: New ex vivo and in vitro data are presented suggesting that human immunoglobulins can interact with tau protein and alter both the dynamics and structural organization of microtubules in AD brains.
Journal ArticleDOI
Disruption of an Evolutionarily Novel Synaptic Expression Pattern in Autism.
Xiling Liu,Xiling Liu,Dingding Han,Mehmet Somel,Mehmet Somel,Xi Jiang,Haiyang Hu,Patricia Guijarro,Ning Zhang,Amanda C. Mitchell,Tobias B. Halene,John J. Ely,Chet C. Sherwood,Patrick R. Hof,Zilong Qiu,Svante Pääbo,Schahram Akbarian,Philipp Khaitovich,Philipp Khaitovich +18 more
TL;DR: This study analyzes gene expression in the prefrontal cortex of 63 autism patients and control individuals, as well as 62 chimpanzees and macaques, from natal to adult age to draw a connection between the genetic risk architecture of autism and molecular features of cortical development unique to humans.
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Differences in Cortical Serotonergic Innervation among Humans, Chimpanzees, and Macaque Monkeys: A Comparative Study
Mary Ann Raghanti,Cheryl D. Stimpson,Jennifer L. Marcinkiewicz,Joseph M. Erwin,Patrick R. Hof,Chet C. Sherwood +5 more
TL;DR: A significant reorganization of cortical serotonergic transmission in humans and chimpanzees is indicated, which may represent a greater capacity for cortical plasticity exclusive to hominoids.
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Regional Distribution of Neurofibrillary Tangles and Senile Plaques in the Cerebral Cortex of Very Old Patients
Panteleimon Giannakopoulos,Patrick R. Hof,Anne-Séverine Giannakopoulos,François Herrmann,Jean-Pierre Michel,Constantin Bouras +5 more
TL;DR: Results indicate that the neuronal degeneration in very old demented patients involves cortical areas usually preserved at the early stages of the dementing process, which may be a pathologic hallmark of the severity of dementia in this particular age group.