P
Peter W. Reeh
Researcher at University of Erlangen-Nuremberg
Publications - 187
Citations - 13190
Peter W. Reeh is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Calcitonin gene-related peptide & TRPV1. The author has an hindex of 61, co-authored 180 publications receiving 12118 citations. Previous affiliations of Peter W. Reeh include Heidelberg University & University of Pécs.
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Journal ArticleDOI
Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors
Nitin Agarwal,Pal Pacher,Irmgard Tegeder,Fumimasa Amaya,Cristina E. Constantin,Gary J. Brenner,Tiziana Rubino,Christoph W. Michalski,Giovanni Marsicano,Krisztina Monory,Ken Mackie,Claudiu Marian,Sandor Batkai,Daniela Parolaro,Michael Fischer,Peter W. Reeh,George Kunos,Michaela Kress,Beat Lutz,Clifford J. Woolf,Rohini Kuner +20 more
TL;DR: It is concluded that the contribution of CB1-type receptors expressed on the peripheral terminals of nociceptors to cannabinoid-induced analgesia is paramount, which should enable the development of peripherally acting CB1 analgesic agonists without any central side effects.
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Methylglyoxal modification of Na v 1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy
Angelika Bierhaus,Thomas Fleming,S. B. Stoyanov,Andreas Leffler,Andreas Leffler,Alexandru Babes,Alexandru Babes,Cristian Neacsu,Susanne K. Sauer,Mirjam Eberhardt,Martina Schnölzer,Felix Lasischka,Winfried Neuhuber,Tatjana I. Kichko,Ilze Konrade,Ralf Elvert,Walter Mier,Valdis Pirags,Ivan K. Lukic,Michael Morcos,Thomas Dehmer,Naila Rabbani,Paul J. Thornalley,Diane Edelstein,Carla Nau,Josephine M. Forbes,Per M. Humpert,Markus Schwaninger,Dan Ziegler,David M. Stern,Mark E. Cooper,Uwe Haberkorn,Michael Brownlee,Peter W. Reeh,Peter P. Nawroth +34 more
TL;DR: It is found that concentrations of plasma methylglyoxal above 600 nM discriminate between diabetes-affected individuals with pain and those without pain, which provides a new basis for the design of therapeutic interventions for painful diabetic neuropathy.
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Sensory neuron sodium channel Nav1.8 is essential for pain at low temperatures.
Katharina Zimmermann,Andreas Leffler,Alexandru Babes,Cruz Miguel Cendán,Richard W. Carr,Jin-ichi Kobayashi,Carla Nau,John N. Wood,Peter W. Reeh +8 more
TL;DR: This work shows that cooling excitable membranes progressively enhances the voltage-dependent slow inactivation of tetrodotoxin-sensitive VGSCs, and presents strong evidence for a specialized role of Nav1.8 in nociceptors as the critical molecule for the perception of cold pain and pain in the cold.
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TREK-1, a K+ channel involved in polymodal pain perception
Abdelkrim Alloui,Katharina Zimmermann,Julien Mamet,Fabrice Duprat,Jacques Noël,Jean Chemin,Nicolas Guy,Nicolas Blondeau,Nicolas Voilley,Catherine Rubat-Coudert,Marc Borsotto,Georges Romey,Catherine Heurteaux,Peter W. Reeh,Alain Eschalier,Michel Lazdunski +15 more
TL;DR: It is demonstrated that TREK‐1 qualifies as one of the molecular sensors involved in pain perception and as an attractive target for the development of new analgesics.
Journal ArticleDOI
TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins
Víctor M. Meseguer,Yeranddy A. Alpizar,Enoch Luis,Sendoa Tajada,Bristol Denlinger,Otto Fajardo,Jan-Albert Manenschijn,Carlos Fernández-Peña,Arturo Talavera,Tatiana Kichko,Belén Navia,Alicia Sanchez,Rosa Señarís,Peter W. Reeh,M. T. Pérez-García,José R. López-López,Thomas Voets,Carlos Belmonte,Karel Talavera,Félix Viana +19 more
TL;DR: This work shows that LPS exerts fast, membrane delimited, excitatory actions via TRPA1, a transient receptor potential cation channel that is critical for transducing environmental irritant stimuli into nociceptor activity, and finds that pain and acute vascular reactions, including neurogenic inflammation (CGRP release) caused by LPS are primarily dependent onTRPA1 channel activation in nocICEptive sensory neurons, and develop independently of TLR4 activation.