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Philippe Vanparys
Researcher at Johnson & Johnson Pharmaceutical Research and Development
Publications - 39
Citations - 2540
Philippe Vanparys is an academic researcher from Johnson & Johnson Pharmaceutical Research and Development. The author has contributed to research in topics: Genotoxicity & Micronucleus test. The author has an hindex of 25, co-authored 39 publications receiving 2398 citations. Previous affiliations of Philippe Vanparys include Johnson & Johnson & Janssen Pharmaceutica.
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Journal ArticleDOI
How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop.
David Kirkland,Stefan Pfuhler,David Tweats,Marilyn J. Aardema,Raffaella Corvi,Firouz Darroudi,Azeddine Elhajouji,Hansruedi Glatt,Paul W. Hastwell,M. Hayashi,Peter Kasper,Stephan Kirchner,Anthony M. Lynch,Daniel Marzin,Daniela Maurici,Jean-Roc Meunier,Lutz Müller,Gerhard J. Nohynek,James M. Parry,Elizabeth M. Parry,Véronique Thybaud,Ray Tice,Jan van Benthem,Philippe Vanparys,Paul D. White +24 more
TL;DR: It was concluded that better guidance on the likely mechanisms resulting in positive results that are not biologically relevant for human health, and how to obtain evidence for those mechanisms, is needed both for practitioners and regulatory reviewers.
Journal ArticleDOI
A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing.
David A. Basketter,Harvey J. Clewell,Ian Kimber,Annamaria Rossi,Bas J. Blaauboer,Robert Burrier,Mardas Daneshian,Chantra Eskes,Alan M. Goldberg,Nina Hasiwa,Sebastian Hoffmann,Joanna Jaworska,Thomas B. Knudsen,Robert Landsiedel,Marcel Leist,Paul A. Locke,Gavin Maxwell,James M. McKim,Emily A. McVey,Gladys Ouedraogo,Grace Patlewicz,Olavi Pelkonen,Erwin Ludo Roggen,Costanza Rovida,Irmela Ruhdel,Michael Schwarz,Andreas Schepky,Greet Schoeters,Nigel Skinner,Kerstin Trentz,Marian Turner,Philippe Vanparys,James D. Yager,Joanne Zurlo,Thomas Hartung +34 more
TL;DR: In this paper, the authors present a roadmap for how to overcome the acknowledged scientific gaps for the full replacement of systemic toxicity testing using animals, which is a major concern for the current state of the art.
Journal ArticleDOI
A core in vitro genotoxicity battery comprising the Ames test plus the in vitro micronucleus test is sufficient to detect rodent carcinogens and in vivo genotoxins.
TL;DR: There is no convincing evidence that any genotoxic rodent carcinogens or in vivo genotoxins would remain undetected in an in vitro test battery consisting of Ames+MNvit.
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A review of the implementation of the embryonic stem cell test (EST). The report and recommendations of an ECVAM/ReProTect Workshop.
P. Marx-Stoelting,Els Adriaens,H. J. Ahr,Susanne Bremer,Bernward Garthoff,H.P. Gelbke,Aldert H. Piersma,Cristian Pellizzer,U. Reuter,Vera Rogiers,B. Schenk,S. Schwengberg,Andrea Seiler,Horst Spielmann,Margino Steemans,D.B. Stedman,Philippe Vanparys,Joan Albert Vericat,M. Verwei,F. van der Water,Michaela Weimer,Michael Schwarz +21 more
TL;DR: Under the REACH system policy, it will be most probably necessary to test several thousand chemicals for their toxicological properties.
Journal ArticleDOI
The practical application of three validated in vitro embryotoxicity tests. The report and recommendations of an ECVAM/ZEBET workshop (ECVAM workshop 57).
Horst Spielmann,Andrea Seiler,Susanne Bremer,Lars Hareng,Thomas Hartung,H.J. Ahr,Elaine M. Faustman,Ulla Haas,Graeme J. Moffat,Heinz Nau,Philippe Vanparys,Aldert H. Piersma,Juan Riego Sintes,Jane Stuart +13 more
TL;DR: The ECVAM Scientific Advisory Committee (ESAC) concluded from the results that the three in vitro embryotoxicity tests had been sufficiently validated and could be applied to the assessment of the embryotoxic potential of drugs and other chemicals.