R
Rafal Pawlinski
Researcher at University of North Carolina at Chapel Hill
Publications - 119
Citations - 7414
Rafal Pawlinski is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Tissue factor & Inflammation. The author has an hindex of 37, co-authored 112 publications receiving 6482 citations. Previous affiliations of Rafal Pawlinski include Scripps Research Institute & Jagiellonian University.
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Journal ArticleDOI
HIF-1α Is Essential for Myeloid Cell-Mediated Inflammation
Thorsten Cramer,Yuji Yamanishi,Björn E. Clausen,Irmgard Förster,Rafal Pawlinski,Nigel Mackman,Volker H. Haase,Rudolf Jaenisch,Maripat Corr,Victor Nizet,Gary S. Firestein,Hans-Peter Gerber,Napoleone Ferrara,Randall S. Johnson +13 more
TL;DR: It is found that activation of HIF-1alpha is essential for myeloid cell infiltration and activation in vivo through a mechanism independent of VEGF, and its direct regulation of survival and function in the inflammatory microenvironment is demonstrated.
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Lipopolysaccharide activation of the MEK-ERK1/2 pathway in human monocytic cells mediates tissue factor and tumor necrosis factor alpha expression by inducing Elk-1 phosphorylation and Egr-1 expression.
Mausumee Guha,Maria A. O'Connell,Maria A. O'Connell,Maria A. O'Connell,Rafal Pawlinski,Rafal Pawlinski,Rafal Pawlinski,Angela Hollis,Angela Hollis,Angela Hollis,Patricia McGovern,Patricia McGovern,Patricia McGovern,Shi Fang Yan,Shi Fang Yan,Shi Fang Yan,David M. Stern,David M. Stern,David M. Stern,Nigel Mackman,Nigel Mackman,Nigel Mackman +21 more
TL;DR: The data indicate that LPS induction of Egr-1 gene expression is required for maximal induction of the TNF-alpha and TF genes in human monocytic cells.
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Role of tissue factor and protease-activated receptors in a mouse model of endotoxemia
Rafal Pawlinski,Brian Pedersen,Gernot Schabbauer,Michael Tencati,Todd Holscher,William A. Boisvert,Patricia Andrade-Gordon,Rolf Dario Frank,Nigel Mackman +8 more
TL;DR: Data demonstrate that hematopoietic cells are the major pathologic site of TF expression during endotoxemia and suggest that multiple protease-activated receptors mediate crosstalk between coagulation and inflammation.
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Dendritic cell PAR1–S1P3 signalling couples coagulation and inflammation
Frank Niessen,Florence Schaffner,Christian Furlan-Freguia,Rafal Pawlinski,Gourab Bhattacharjee,Jerold Chun,Claudia K. Derian,Patricia Andrade-Gordon,Hugh Rosen,Wolfram Ruf +9 more
TL;DR: In this article, the sphingosine 1-phosphate (S1P) axis is a downstream component of PAR1 signalling, and by combining chemical and genetic probes for S1P receptor 3, they show a critical role for dendritic cell PAR1-S 1P3 cross-talk in regulating amplification of inflammation in sepsis syndrome.
Journal ArticleDOI
The thrombomodulin-protein C system is essential for the maintenance of pregnancy.
Berend Isermann,Rashmi Sood,Rafal Pawlinski,Mark Zogg,Shawn Kalloway,Jay L. Degen,Nigel Mackman,Hartmut Weiler,Hartmut Weiler +8 more
TL;DR: Findings show a new function for the thrombomodulin–protein C system in controlling the growth and survival of trophoblast cells in the placenta, essential for the maintenance of pregnancy.