R
Roland James
Researcher at Medical College of Wisconsin
Publications - 16
Citations - 1495
Roland James is an academic researcher from Medical College of Wisconsin. The author has contributed to research in topics: Adipose tissue & Body mass index. The author has an hindex of 13, co-authored 15 publications receiving 1342 citations.
Papers
More filters
Journal ArticleDOI
Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome
Ahmed H. Kissebah,Gabriele E. Sonnenberg,Joel B. Myklebust,Michael D. Goldstein,Karl W. Broman,Roland James,Jacqueline Marks,Glenn R. Krakower,Howard J. Jacob,James L. Weber,Lisa J. Martin,John Blangero,Anthony G. Comuzzie +12 more
TL;DR: Pedigree-based analysis using a variance components linkage model demonstrated a quantitative trait locus (QTL) on chromosome 3 (3q27) strongly linked to six traits representing these fundamental phenotypes, and candidate genes likely to influence two biologic precursor pathways of the metabolic syndrome are identified.
Journal ArticleDOI
Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations
M. Geoffrey Hayes,Margrit Urbanek,David A. Ehrmann,Loren L. Armstrong,Ji Young Lee,Ryan Sisk,Tugce Karaderi,Thomas M. Barber,Mark I. McCarthy,Stephen Franks,Cecilia M. Lindgren,Cecilia M. Lindgren,Corrine K. Welt,Evanthia Diamanti-Kandarakis,Dimitrios Panidis,Mark O. Goodarzi,Ricardo Azziz,Yi Zhang,Roland James,Michael Olivier,Ahmed H. Kissebah,Elisabet Stener-Victorin,Richard S. Legro,Andrea Dunaif,Ruben Alvero,Huiman X. Barnhart,Valerie L. Baker,Kurt T. Barnhart,G. Wright Bates,Robert G. Brzyski,Bruce R. Carr,Sandra Ann Carson,Peter R. Casson,Nicholas A. Cataldo,Gregory M. Christman,Christos Coutifaris,Michael P. Diamond,Esther Eisenberg,Gabriella G. Gosman,Linda C. Giudice,Daniel J. Haisenleder,Hao Huang,Stephen A. Krawetz,Scott Lucidi,Peter G. McGovern,Evan R. Myers,John E. Nestler,Dana A. Ohl,Nanette Santoro,William D. Schlaff,Peter J. Snyder,Michael P. Steinkampf,J. C. Trussell,Rebecca S. Usadi,Qingshang Yan,Heping Zhang +55 more
TL;DR: Common genetic susceptibility loci in European ancestry women for the National Institutes of Health PCOS phenotype are identified, which confers the highest risk for metabolic morbidities, as well as reproductive hormone levels, and implicate neuroendocrine changes in disease pathogenesis.
Journal ArticleDOI
Obesity, central adiposity and cardiometabolic risk factors in children and adolescents: a family-based study.
TL;DR: The objective of this study was to assess genetic and phenotypic correlations of obesity‐related cardiometabolic risk factors in a family‐based cohort.
Journal ArticleDOI
Adiponectin Levels Differentiate Metabolically Healthy vs Unhealthy Among Obese and Nonobese White Individuals
Scott Ahl,Mitchell Guenther,Shi Zhao,Roland James,Jacqueline Marks,Aniko Szabo,Srividya Kidambi +6 more
TL;DR: Higher ADPN and lower WHRs (higher peripheral adiposity) are associated with better metabolic health in both nonobese and obese white individuals, and these results suggest that ADPN & adiposity play a key role in determining the metabolic health independent of body mass index.
Journal ArticleDOI
Methylation of SOCS3 is inversely associated with metabolic syndrome in an epigenome-wide association study of obesity
TL;DR: It is concluded that epigenetic modulation of SOCS3, a gene involved in leptin and insulin signaling, may play an important role in obesity and MetS.