S
Sergey I. Moskovtsev
Researcher at University of Toronto
Publications - 58
Citations - 2222
Sergey I. Moskovtsev is an academic researcher from University of Toronto. The author has contributed to research in topics: Sperm & Semen. The author has an hindex of 24, co-authored 52 publications receiving 1782 citations. Previous affiliations of Sergey I. Moskovtsev include Mount Sinai Hospital, Toronto & University of Utah.
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Journal ArticleDOI
DNA Integrity Is Compromised in Protamine‐Deficient Human Sperm
Vincent W. Aoki,Sergey I. Moskovtsev,Jennifer Willis,Lihua Liu,Brendan Mullen,Douglas T. Carrell +5 more
TL;DR: Sperm P1 and P2 concentrations inversely correlate with DNA fragmentation, indicating a protective role of the protamines against sperm DNA damage, and a possible clinical significance for human sperm protamine levels.
Journal ArticleDOI
Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility
Ashok Agarwal,Neel Parekh,Manesh Kumar Panner Selvam,Ralf Henkel,Ralf Henkel,Rupin Shah,Sheryl T. Homa,Ranjith Ramasamy,Edmund Y. Ko,Kelton Tremellen,Sandro C. Esteves,Sandro C. Esteves,Ahmad Majzoub,Ahmad Majzoub,Juan G. Alvarez,David K. Gardner,Channa N. Jayasena,Channa N. Jayasena,Jonathan Ramsay,Chak-Lam Cho,Ramadan A Saleh,Denny Sakkas,James M. Hotaling,Scott Lundy,Sarah C. Vij,Joel L. Marmar,Jaime Gosálvez,Edmund Sabanegh,Hyun Jun Park,Armand Zini,Parviz Kavoussi,Sava Micic,Ryan P. Smith,Gian Maria Busetto,Mustafa Emre Bakircioglu,Gerhard Haidl,Giancarlo Balercia,Nicolás Garrido Puchalt,Moncef Ben-Khalifa,Nicholas N. Tadros,Jackson Kirkman-Browne,Sergey I. Moskovtsev,Xuefeng Huang,Edson Borges,Daniel R. Franken,Natan Bar-Chama,Yoshiharu Morimoto,Kazuhisa Tomita,Vasan Satya Srini,Willem Ombelet,Elisabetta Baldi,Monica Muratori,Yasushi Yumura,Sandro La Vignera,Raghavender Kosgi,Marlon Martinez,Donald P. Evenson,Daniel Suslik Zylbersztejn,Matheus Roque,Marcello Cocuzza,Marcelo Vieira,Assaf Ben-Meir,Raoul Orvieto,Raoul Orvieto,Eliahu Levitas,Amir Wiser,Amir Wiser,Mohamed Arafa,Vineet Malhotra,Sijo Parekattil,Haitham Elbardisi,Luiz Carvalho,Rima Dada,Christophe Sifer,Pankaj Talwar,Ahmet Gudeloglu,Ahmed M A Mahmoud,Khaled Terras,Chadi Yazbeck,Bojanic Nebojsa,Damayanthi Durairajanayagam,Ajina Mounir,Linda G. Kahn,Saradha Baskaran,Rishma Pai,Donatella Paoli,Kristian Leisegang,Mohamed Reza Moein,Sonia Malik,Önder Yaman,Luna Samanta,Fouad Bayane,Sunil Jindal,Muammer Kendirci,Barış Altay,Dragoljub Perovic,Avi Harlev +96 more
TL;DR: Oxidation-reduction potential (ORP) can be a useful clinical biomarker for the classification of MOSI, as it takes into account the levels of both oxidants and reductants (antioxidants) and may provide a more targeted, reliable approach for administering antioxidant therapy while minimizing the risk of antioxidant overdose.
Journal ArticleDOI
Absence of sperm RNA elements correlates with idiopathic male infertility.
Meritxell Jodar,Edward Sendler,Sergey I. Moskovtsev,Clifford Librach,Robert Goodrich,Sonja A. Swanson,Russ Hauser,Michael P. Diamond,Stephen A. Krawetz +8 more
TL;DR: The data in this study suggest that SRE analysis has the potential to predict the individual success rate of different fertility treatments and reduce the time to achieve live birth.
Journal ArticleDOI
Age-related decline in sperm deoxyribonucleic acid integrity in patients evaluated for male infertility
TL;DR: It was found that men 45 years and older had significantly greater DNA fragmentation than younger men.
Journal ArticleDOI
Human spermatogenic failure purges deleterious mutation load from the autosomes and both sex chromosomes, including the gene DMRT1.
Alexandra M. Lopes,Kenneth I. Aston,Emma E. Thompson,Filipa Carvalho,João Gonçalves,Ni Huang,Rune Matthiesen,Michiel J. Noordam,Inés Quintela,Avinash Ramu,Catarina M. Seabra,Amy B. Wilfert,Juncheng Dai,Jonathan M. Downie,Susana Fernandes,Xuejiang Guo,Jiahao Sha,António Amorim,Alberto Barros,Angel Carracedo,Zhibin Hu,Matthew E. Hurles,Sergey I. Moskovtsev,Carole Ober,Darius A. Paduch,Joshua D. Schiffman,Peter N. Schlegel,Mário Sousa,Douglas T. Carrell,Donald F. Conrad +29 more
TL;DR: The combined results indicate that DMRT1 loss-of-function mutations are a risk factor and potential genetic cause of human spermatogenic failure and identifies other recurrent CNVs as potential causes of idiopathic azoospermia.