Robert A. Budinsky

TL;DR: This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro and how closely hepatoma, stem cell and iPS cell–derived hepatocyte-like-cells resemble real hepatocytes.

TL;DR: In this paper, the authors identified 90 studies on mixtures and identified synergism in mammalian test systems, with emphasis on studies performed at doses close to the points of departure (PODs) for individual chemicals.

TL;DR: A scientific confidence framework for evaluating and applying a given AOP for different regulatory purposes ranging from prioritizing chemicals for further evaluation, to hazard prediction, and ultimately, risk assessment is proposed.

TL;DR: The present data indicate that the AHR may play significantly different roles in tissue development and homeostasis and toxicity across rodent species.

TL;DR: Evidence is provided for divergent cross-species gene expression changes in response to TCDD and is consistent with epidemiological and clinical evidence showing humans to be less sensitive to T CDD-induced hepatotoxicity.