J
Jian Dong
Researcher at Research Triangle Park
Publications - 7
Citations - 1295
Jian Dong is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Gene silencing & Transcription factor. The author has an hindex of 7, co-authored 7 publications receiving 1122 citations. Previous affiliations of Jian Dong include Wuhan University of Science and Technology & COMSATS Institute of Information Technology.
Papers
More filters
Journal ArticleDOI
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.
Patricio Godoy,Nicola J. Hewitt,Ute Albrecht,Melvin E. Andersen,Nariman Ansari,Sudin Bhattacharya,Johannes G. Bode,Jennifer Bolleyn,Christoph Borner,J Böttger,Albert Braeuning,Robert A. Budinsky,Britta Burkhardt,Neil R. Cameron,Giovanni Camussi,Chong Su Cho,Yun Jaie Choi,J. Craig Rowlands,Uta Dahmen,Georg Damm,Olaf Dirsch,María Teresa Donato,Jian Dong,Steven Dooley,Dirk Drasdo,Dirk Drasdo,Dirk Drasdo,Rowena Eakins,Karine Sá Ferreira,Valentina Fonsato,Joanna Fraczek,Rolf Gebhardt,Andrew Gibson,Matthias Glanemann,Christopher E. Goldring,María José Gómez-Lechón,Geny M. M. Groothuis,Lena Gustavsson,Christelle Guyot,David Hallifax,Seddik Hammad,Adam S. Hayward,Dieter Häussinger,Claus Hellerbrand,Philip Hewitt,Stefan Hoehme,Hermann-Georg Holzhütter,J. Brian Houston,Jens Hrach,Kiyomi Ito,Hartmut Jaeschke,Verena Keitel,Jens M. Kelm,B. Kevin Park,Claus Kordes,Gerd A. Kullak-Ublick,Edward L. LeCluyse,Peng Lu,Jennifer Luebke-Wheeler,Anna Lutz,Daniel J. Maltman,Madlen Matz-Soja,Patrick D. McMullen,Irmgard Merfort,Simon Messner,Christoph Meyer,Jessica Mwinyi,Dean J. Naisbitt,Andreas K. Nussler,Peter Olinga,Francesco Pampaloni,Jingbo Pi,Linda J. Pluta,Stefan Przyborski,Anup Ramachandran,Vera Rogiers,Cliff Rowe,Celine Schelcher,Kathrin Schmich,Michael Schwarz,Bijay Singh,Ernst H. K. Stelzer,Bruno Stieger,Regina Stöber,Yuichi Sugiyama,Ciro Tetta,Wolfgang E. Thasler,Tamara Vanhaecke,Mathieu Vinken,Thomas S. Weiss,Agata Widera,Courtney G. Woods,Jinghai James Xu,Kathy Yarborough,Jan G. Hengstler +94 more
TL;DR: This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro and how closely hepatoma, stem cell and iPS cell–derived hepatocyte-like-cells resemble real hepatocytes.
Journal ArticleDOI
CNC-bZIP Protein Nrf1-Dependent Regulation of Glucose-Stimulated Insulin Secretion
Hongzhi Zheng,Jingqi Fu,Jingqi Fu,Peng Xue,Peng Xue,Rui Zhao,Jian Dong,Jian Dong,Dianxin Liu,Masayuki Yamamoto,Qingchun Tong,Weiping Teng,Weidong Qu,Qiang Zhang,Melvin E. Andersen,Jingbo Pi,Jingbo Pi +16 more
TL;DR: A novel role of Nrf1 is demonstrated in regulating glucose metabolism and insulin secretion in β-cells and NRF1 is characterized as a key transcription factor that regulates the coupling of glycolysis and mitochondrial metabolism and GSIS.
Journal ArticleDOI
Regulatory role of KEAP1 and NRF2 in PPARγ expression and chemoresistance in human non-small-cell lung carcinoma cells
Lijuan Zhan,Hao Zhang,Hao Zhang,Qiang Zhang,Courtney G. Woods,Yanyan Chen,Yanyan Chen,Peng Xue,Jian Dong,Erik J. Tokar,Yuanyuan Xu,Yongyong Hou,Jingqi Fu,Kathy Yarborough,Aiping Wang,Weidong Qu,Michael P. Waalkes,Melvin E. Andersen,Jingbo Pi +18 more
TL;DR: In this article, a stable knockdown of Kelch-like ECH-associated protein 1 (KEAP1) by lentiviral shRNA sensitized three independent NSCLC cell lines to multiple chemotherapeutic agents, including arsenic trioxide (As(2)O(3)), etoposide, and doxorubicin, despite moderately increased NRF2 levels.
Journal ArticleDOI
Suppression of NRF2-ARE activity sensitizes chemotherapeutic agent-induced cytotoxicity in human acute monocytic leukemia cells.
Hui Peng,Huihui Wang,Peng Xue,Yongyong Hou,Jian Dong,Tong Zhou,Weidong Qu,Shuangqing Peng,Jin Li,Paul L. Carmichael,Bud Nelson,Rebecca A. Clewell,Qiang Zhang,Melvin E. Andersen,Jingbo Pi,Jingbo Pi +15 more
TL;DR: The present study is the first to demonstrate that ethionamide suppresses NRF2-ARE signaling and disrupts the transcriptional network of the antioxidant response in AML cells, leading to sensitization to chemotherapeutic agents.
Journal ArticleDOI
Long isoforms of NRF1 negatively regulate adipogenesis via suppression of PPARγ expression.
Peng Xue,Yongyong Hou,Zhuo Zuo,Zhendi Wang,Suping Ren,Jian Dong,Jingqi Fu,Huihui Wang,Melvin E. Andersen,Qiang Zhang,Yuanyuan Xu,Jingbo Pi +11 more
TL;DR: The findings in the present study provide further evidence for a novel role of NRF1 beyond its participation in cellular antioxidant response and suggest that L-NRF1 is a negative regulator of PPARγ2 expression and thereby can suppress adipogenesis.