S
Steven G. Hershman
Researcher at Stanford University
Publications - 28
Citations - 1302
Steven G. Hershman is an academic researcher from Stanford University. The author has contributed to research in topics: Medicine & Gene. The author has an hindex of 10, co-authored 23 publications receiving 972 citations. Previous affiliations of Steven G. Hershman include Harvard University & University of Pennsylvania.
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Journal ArticleDOI
Molecular diagnosis of infantile mitochondrial disease with targeted next-generation sequencing
Sarah E. Calvo,Alison G. Compton,Steven G. Hershman,Steven G. Hershman,Sze Chern Lim,Sze Chern Lim,Daniel S. Lieber,Daniel S. Lieber,Elena J. Tucker,Elena J. Tucker,Adrienne Laskowski,Caterina Garone,Caterina Garone,Shangtao Liu,David B. Jaffe,John Christodoulou,John Christodoulou,Janice M. Fletcher,Damien L. Bruno,Jack Goldblatt,Salvatore DiMauro,David R. Thorburn,David R. Thorburn,Vamsi K. Mootha,Vamsi K. Mootha +24 more
TL;DR: target NGS in 42 unrelated infants with clinical and biochemical evidence of mitochondrial oxidative phosphorylation disease suggests that next-generation sequencing may be able to provide a molecular diagnosis for ~25% of currently unsolved cases of infantile mitochondrial disease.
Journal ArticleDOI
Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise.
James A. Sanford,Christopher D. Nogiec,Malene E. Lindholm,Joshua N. Adkins,David Amar,Surendra Dasari,Jonelle K. Drugan,Facundo M. Fernández,Shlomit Radom-Aizik,Simon Schenk,Michael Snyder,Russell P. Tracy,Patrick M. Vanderboom,Scott Trappe,Martin J. Walsh,Charles R. Evans,Yafeng Li,Lyl Tomlinson,D. Lee Alekel,Iddil Bekirov,Amanda T. Boyce,Josephine Boyington,Jerome L. Fleg,Lyndon Joseph,Maren R. Laughlin,Padma Maruvada,Stephanie A. Morris,Joan McGowan,Concepcion R. Nierras,Vinay Pai,Charlotte A. Peterson,Ed Ramos,Mary Roary,John P. Williams,Ashley Xia,Elaine Cornell,Jessica Rooney,Michael Miller,Walter T. Ambrosius,Scott Rushing,Cynthia L. Stowe,W. Jack Rejeski,Barbara J. Nicklas,Marco Pahor,Ching-ju Lu,Todd A. Trappe,Toby Chambers,Ulrika Raue,Bridget Lester,Bryan C. Bergman,David H. Bessesen,Catherine M. Jankowski,Wendy M. Kohrt,Edward L. Melanson,Kerrie L. Moreau,Irene E. Schauer,Robert S. Schwartz,William E. Kraus,Cris A. Slentz,Kim M. Huffman,Johanna L. Johnson,Leslie H. Willis,L S. Kelly,Joseph A. Houmard,Gabriel S. Dubis,Nick Broskey,Bret H. Goodpaster,Lauren M. Sparks,Paul M. Coen,Dan M. Cooper,Fadia Haddad,Tuomo Rankinen,Eric Ravussin,Neil M. Johannsen,Melissa Harris,John M. Jakicic,Anne B. Newman,Daniel Forman,Erin E. Kershaw,Renee J. Rogers,Bradley C. Nindl,Lindsay C. Page,Maja Stefanovic-Racic,Susan Barr,Blake B. Rasmussen,Tatiana Moro,Doug Paddon-Jones,Elena Volpi,Heidi Spratt,Nicolas Musi,Sara E. Espinoza,Darpan I. Patel,Monica C. Serra,Jonathan Gelfond,Aisling Burns,Marcas M. Bamman,Thomas W. Buford,Gary Cutter,Sue C. Bodine,Karyn A. Esser,Rodger P. Farrar,Laurie J. Goodyear,Michael F. Hirshman,Brent G. Albertson,Wei-Jun Qian,Paul D. Piehowski,Marina A. Gritsenko,Matthew E. Monore,Vladislav A. Petyuk,Jason E. McDermott,Joshua N. Hansen,Chelsea Hutchison,Samuel G. Moore,David A. Gaul,Clary B. Clish,Julian Avila-Pacheco,Courtney Dennis,Manolis Kellis,Steve Carr,Pierre M. Jean-Beltran,Hasmik Keshishian,D. R. Mani,Karl R. Clauser,Karsten Krug,Charlie Mundorff,Cadence Pearce,Anna A. Ivanova,Eric A. Ortlund,Kristal M. Maner-Smith,Karan Uppal,Tiantian Zhang,Stuart C. Sealfon,Elena Zaslavsky,Venugopalan D. Nair,SiDe Li,Nimisha Jain,Yongchao Ge,Yifei Sun,German Nudelman,Frederique Ruf-Zamojski,Gregory R. Smith,Nhanna Pincas,Aliza B. Rubenstein,Mary Anne S. Amper,Nitish Seenarine,Tuuli Lappalainen,Ian R. Lanza,K. Sreekumaran Nair,Katherine Klaus,Stephen B. Montgomery,Kevin S. Smith,Bingqing Zhao,Chia-Jiu Hung,Navid Zebarjadi,Brunilda Balliu,Laure Fresard,Charles F. Burant,Jun Li,Maureen Kachman,Tanu Soni,Alexander B. Raskind,Robert E. Gerszten,Jeremy M. Robbins,Olga Ilkayeva,Michael J. Muehlbauer,Christopher B. Newgard,Euan A. Ashley,Matthew T. Wheeler,David Jimenez-Morales,Archana Raja,Karen P. Dalton,Jimmy Zhen,Young Suk Kim,Jeffrey W. Christle,Shruti Marwaha,Elizabeth T Chin,Steven G. Hershman,Trevor Hastie,Robert Tibshirani,Manuel A. Rivas +179 more
TL;DR: The Molecular Transducers of Physical Activity Consortium (MoTrPAC) will provide a public database that is expected to enhance the understanding of the health benefits of exercise and to provide insight into how physical activity mitigates disease.
Journal ArticleDOI
The Asthma Mobile Health Study, a large-scale clinical observational study using ResearchKit
Yu-Feng Yvonne Chan,Pei Wang,Linda Rogers,Nicole Tignor,Micol Zweig,Steven G. Hershman,Nicholas Genes,Erick R. Scott,Eric Krock,Marcus A. Badgeley,Ron Edgar,Samantha Violante,Rosalind J. Wright,Charles A. Powell,Joel T. Dudley,Eric E. Schadt +15 more
TL;DR: Initial findings from the Asthma Mobile Health Study are reported, a research study, including recruitment, consent, and enrollment, conducted entirely remotely by smartphone, that detected increased reporting of asthma symptoms in regions affected by heat, pollen, and wildfires.
Journal ArticleDOI
Targeted exome sequencing of suspected mitochondrial disorders
Daniel S. Lieber,Sarah E. Calvo,Kristy Shanahan,Nancy G. Slate,Shangtao Liu,Steven G. Hershman,Nina B. Gold,Brad Chapman,David R. Thorburn,Gerard T. Berry,Jeremy D. Schmahmann,Mark L. Borowsky,David M. Mueller,Katherine B. Sims,Vamsi K. Mootha +14 more
TL;DR: Targeted exome sequencing is an effective alternative to the sequential testing of mtDNA and individual nuclear genes as part of the investigation of mitochondrial disease and underscores the ongoing challenge of variant interpretation in the clinical setting.
Journal ArticleDOI
Mutations in MTFMT Underlie a Human Disorder of Formylation Causing Impaired Mitochondrial Translation
Elena J. Tucker,Steven G. Hershman,Steven G. Hershman,Caroline Köhrer,Casey A. Belcher-Timme,Casey A. Belcher-Timme,Jinal Patel,Olga Goldberger,Olga Goldberger,John Christodoulou,John Christodoulou,Jonathon M. Silberstein,Matthew McKenzie,Michael T. Ryan,Alison G. Compton,Jacob D. Jaffe,Steven A. Carr,Sarah E. Calvo,Sarah E. Calvo,Uttam L. RajBhandary,David R. Thorburn,David R. Thorburn,Vamsi K. Mootha,Vamsi K. Mootha +23 more
TL;DR: It is demonstrated that MTFMT is critical for efficient human mitochondrial translation and a human disorder of Met-tRNA(Met) formylation is revealed.