V
Vagheesh M. Narasimhan
Researcher at Harvard University
Publications - 25
Citations - 3790
Vagheesh M. Narasimhan is an academic researcher from Harvard University. The author has contributed to research in topics: Population & Medicine. The author has an hindex of 15, co-authored 19 publications receiving 2796 citations. Previous affiliations of Vagheesh M. Narasimhan include Wellcome Trust Sanger Institute & University of Texas at Austin.
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Journal ArticleDOI
Metagenomic microbial community profiling using unique clade-specific marker genes.
Nicola Segata,Levi Waldron,Annalisa Ballarini,Vagheesh M. Narasimhan,Olivier Jousson,Curtis Huttenhower +5 more
TL;DR: This work presents an approach that uses clade-specific marker genes to unambiguously assign reads to microbial clades more accurately and >50× faster than current approaches, and validated the metagenomic phylogenetic analysis tool, MetaPhlAn, on terabases of short reads.
Journal ArticleDOI
BCFtools/RoH: a hidden Markov model approach for detecting autozygosity from next-generation sequencing data
TL;DR: BCFtools/RoH is presented and evaluated, an extension to the BCFtools software package, that detects regions of autozygosity in sequencing data, in particular exome data, using a hidden Markov model and it is shown that it has higher sensitivity and specificity than existing methods under a range of sequencing error rates and levels of autozykgosity.
Journal ArticleDOI
The Formation of Human Populations in South and Central Asia
Vagheesh M. Narasimhan,Nick Patterson,Nick Patterson,Priya Moorjani,Nadin Rohland,Nadin Rohland,Rebecca Bernardos,Swapan Mallick,Swapan Mallick,Swapan Mallick,Iosif Lazaridis,Nathan Nakatsuka,Nathan Nakatsuka,Iñigo Olalde,Mark Lipson,Alexander M. Kim,Luca M. Olivieri,Alfredo Coppa,Massimo Vidale,James Mallory,Vyacheslav Moiseyev,Egor Kitov,Egor Kitov,Janet Monge,Nicole Adamski,Nicole Adamski,Neel Alex,Nasreen Broomandkhoshbacht,Nasreen Broomandkhoshbacht,Francesca Candilio,Kimberly Callan,Kimberly Callan,Olivia Cheronet,Olivia Cheronet,Brendan J. Culleton,Matthew Ferry,Matthew Ferry,Daniel Fernandes,Suzanne Freilich,Beatriz Gamarra,Daniel Gaudio,Mateja Hajdinjak,Eadaoin Harney,Eadaoin Harney,Thomas K. Harper,Denise Keating,Ann Marie Lawson,Ann Marie Lawson,Matthew Mah,Matthew Mah,Matthew Mah,Kirsten Mandl,Megan Michel,Megan Michel,Mario Novak,Jonas Oppenheimer,Jonas Oppenheimer,Niraj Rai,Niraj Rai,Kendra Sirak,Kendra Sirak,Kendra Sirak,Viviane Slon,Kristin Stewardson,Kristin Stewardson,Fatma Zalzala,Fatma Zalzala,Zhao Zhang,Gaziz Akhatov,Anatoly N. Bagashev,Alessandra Bagnera,Bauryzhan Baitanayev,Julio Bendezu-Sarmiento,Arman A. Bissembaev,Gian Luca Bonora,T Chargynov,T. A. Chikisheva,Petr K. Dashkovskiy,Anatoly P. Derevianko,Miroslav Dobeš,Katerina Douka,Katerina Douka,Nadezhda Dubova,Meiram N. Duisengali,Dmitry Enshin,Andrey Epimakhov,Alexey Fribus,Dorian Q. Fuller,Dorian Q. Fuller,Alexander Goryachev,Andrey Gromov,S. P. Grushin,Bryan Hanks,Margaret A. Judd,Erlan Kazizov,Aleksander Khokhlov,Aleksander P. Krygin,Elena Kupriyanova,Pavel Kuznetsov,Donata Luiselli,Farhod Maksudov,Aslan M. Mamedov,Talgat B. Mamirov,Christopher Meiklejohn,Deborah C. Merrett,Roberto Micheli,Oleg Mochalov,Samariddin Mustafokulov,Ayushi Nayak,Davide Pettener,Richard Potts,Dmitry Razhev,Marina Petrovna Rykun,Stefania Sarno,Tatyana M. Savenkova,Kulyan Sikhymbaeva,Sergey Mikhailovich Slepchenko,Oroz A. Soltobaev,Nadezhda Stepanova,Svetlana V. Svyatko,Svetlana V. Svyatko,Kubatbek Tabaldiev,Maria Teschler-Nicola,Maria Teschler-Nicola,Alexey A. Tishkin,Vitaly V. Tkachev,Sergey Vasilyev,Petr Velemínský,Dmitriy Voyakin,Antonina Yermolayeva,Muhammad Zahir,Muhammad Zahir,Valery S. Zubkov,A. V. Zubova,Vasant Shinde,Carles Lalueza-Fox,Matthias Meyer,David W. Anthony,Nicole Boivin,Kumarasamy Thangaraj,Douglas J. Kennett,Douglas J. Kennett,Michael D. Frachetti,Ron Pinhasi,Ron Pinhasi,David Reich +145 more
TL;DR: It is shown that Steppe ancestry then integrated further south in the first half of the second millennium BCE, contributing up to 30% of the ancestry of modern groups in South Asia, supporting the idea that the archaeologically documented dispersal of domesticates was accompanied by the spread of people from multiple centers of domestication.
Journal ArticleDOI
Mountain gorilla genomes reveal the impact of long-term population decline and inbreeding
Yali Xue,Javier Prado-Martinez,Peter H. Sudmant,Vagheesh M. Narasimhan,Vagheesh M. Narasimhan,Qasim Ayub,Michal Szpak,Peter Frandsen,Yuan Chen,Bryndis Yngvadottir,David Neil Cooper,Marc de Manuel,Jessica Hernandez-Rodriguez,Irene Lobon,Hans R. Siegismund,Luca Pagani,Luca Pagani,Michael A. Quail,Christina Hvilsom,Antoine Mudakikwa,Evan E. Eichler,Evan E. Eichler,Michael R. Cranfield,Tomas Marques-Bonet,Chris Tyler-Smith,Aylwyn Scally +25 more
TL;DR: It is found that the two eastern subspecies have experienced a prolonged population decline over the past 100,000 years, resulting in very low genetic diversity and an increased overall burden of deleterious variation.
Journal ArticleDOI
Extensive Proliferation of a Subset of Differentiated, yet Plastic, Medial Vascular Smooth Muscle Cells Contributes to Neointimal Formation in Mouse Injury and Atherosclerosis Models.
Joel Chappell,Jennifer L. Harman,Vagheesh M. Narasimhan,Haixiang Yu,Kirsty Foote,Benjamin D. Simons,Martin R. Bennett,Helle F. Jørgensen +7 more
TL;DR: This research presents a novel probabilistic approach that allows us to assess the importance of knowing the carrier and removal status of canine coronavirus, as a source of infection for other animals.