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Wenqiu Wang
Researcher at University of California, San Diego
Publications - Â 16
Citations - Â 1933
Wenqiu Wang is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Protein aggregation & DNA methylation. The author has an hindex of 11, co-authored 15 publications receiving 1287 citations. Previous affiliations of Wenqiu Wang include Shanghai Jiao Tong University.
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Journal ArticleDOI
SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform
John M. Hatcher,Guowei Wu,Chuyue Zeng,Jie Zhu,Jie Zhu,Fan Meng,Sherrina Patel,Wenqiu Wang,Scott B. Ficarro,Scott B. Ficarro,Alan L. Leggett,Chelsea E. Powell,Jarrod A. Marto,Jarrod A. Marto,Kang Zhang,Jacky Chi Ki Ngo,Xiang-Dong Fu,Tinghu Zhang,Nathanael S. Gray +18 more
TL;DR: The development of the first irreversible SRPK inhibitor, SRPKIN-1, which is also the first kinase inhibitor that forms a covalent bond with a tyrosine phenol group in the ATP-binding pocket is reported.
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P16INK4a Upregulation Mediated by SIX6 Defines Retinal Ganglion Cell Pathogenesis in Glaucoma
Dorota Skowronska-Krawczyk,Ling Zhao,Ling Zhao,Jie Zhu,Jie Zhu,Robert N. Weinreb,Guiqun Cao,Jing Luo,Ken Flagg,Sherrina Patel,Cindy Wen,Martin Krupa,Hongrong Luo,Hong Ouyang,Hong Ouyang,Danni Lin,Wenqiu Wang,Wenqiu Wang,Gen Li,Yanxin Xu,Oulan Li,Christopher Chung,Emily Yeh,Maryam Jafari,Michael Ai,Zheng Zhong,William Shi,Lianghong Zheng,Michal Krawczyk,Daniel Chen,Catherine Shi,Carolyn Zin,Jin Zhu,Pamela L. Mellon,Weiwei Gao,Ruben Abagyan,Liangfang Zhang,Xiaodong Sun,Sheng Zhong,Yehong Zhuo,Michael G. Rosenfeld,Yizhi Liu,Kang Zhang +42 more
TL;DR: It is demonstrated that the genetic effect of the SIX6 risk variant is enhanced by another major POAG risk gene, p16INK4a, which leads to RGC senescence in adult human retinas, providing a unified theory of glaucoma pathogenesis.
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Gene and mutation independent therapy via CRISPR-Cas9 mediated cellular reprogramming in rod photoreceptors.
Jie Zhu,Chang Ming,Xin Fu,Xin Fu,Yaou Duan,Duc Anh Hoang,Jeffrey Rutgard,Runze Zhang,Wenqiu Wang,Rui Hou,Daniel Zhang,Edward Zhang,Charlotte Zhang,Xiaoke Hao,Wenjun Xiong,Kang Zhang,Kang Zhang,Kang Zhang +17 more
TL;DR: In this paper, gene and mutation independent therapy via CRISPR-Cas9 mediated cellular reprogramming in rod photoreceptors was performed via gene-and mutation-independent therapy.
Journal ArticleDOI
3D bioprinting of hydrogels for retina cell culturing.
TL;DR: A strategy of integrating the physical and chemical signals through 3D-bioprinting of hyaluronic acid hydrogels and co-differentiation of retinal progenitor cells (RPCs) into PRs with the support of Retinal-pigment epithelium (RPEs) is presented.
Journal ArticleDOI
Copy Number Variations with Isolated Fetal Ventriculomegaly.
Ping Hu,Yong Wang,R Sun,Li Cao,X Chen,C Liu,C Luo,Dingyuan Ma,Wenqiu Wang,Xin Fu,William Shi,Shaohua Yi,Kang Zhang,Hailiang Liu,Zhengfeng Xu +14 more
TL;DR: This study suggests an association between pCNVs may be involved in the pathological process of fetal IMV and postnatal NDs and identifies specific genomic alterations that may provide an insight into pathogenetic mechanism and aid better diagnosis and prognosis of neurodevelopmental outcomes in fetal IMv.