Yosr Hamdi

TL;DR: An insight into the interaction of the viral spike Receptor Binding Domain (RBD) from different coronavirus isolates with host ACE2 protein is provided and corroborates the opinion that the interface segment of the spike protein RBD might be acquired by SARS-CoV-2 via a complex evolutionary process rather than a progressive accumulation of mutations.

TL;DR: In this paper, the authors identified the most promising preventive and treatment approaches available in Africa and analyzed the incidence and fatality rates for the 10 most common and fatal cancers in 56 African countries grouped into five different regions (North, West, East, Central and South) over 16-years (2002-2018).

TL;DR: An insight into the interaction of the viral spike Receptor Binding Domain (RBD) from different coronavirus isolates with host ACE2 protein is provided and corroborates the opinion that the interface segment of the spike protein RBD might be acquired by SARS-CoV-2 via a complex evolutionary process rather than a progressive accumulation of mutations.

TL;DR: It is hypothesized that polymorphisms that alter the expression and/or function of BRCA1 carried on the wild-type (non-mutated) copy of the BRCa1 gene would modify the risk of breast cancer in carriers of BrcA1 mutations, and this effect may be attributed to the differential binding affinity of nuclear proteins.

TL;DR: The main demographic features of North African populations are their familial structure and high rates of familial and geographic endogamy, which have a proven impact on health, particularly the occurrence of genetic diseases, with a greater effect on the frequency and spectrum of the rarest forms of autosomal recessive genetic diseases.