Y
Yuanlin Guan
Publications - 14
Citations - 5499
Yuanlin Guan is an academic researcher. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 3, co-authored 4 publications receiving 4328 citations.
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Journal ArticleDOI
A metagenome-wide association study of gut microbiota in type 2 diabetes
Junjie Qin,Yingrui Li,Zhiming Cai,Shenghui Li,Jianfeng Zhu,Fan Zhang,Suisha Liang,Wenwei Zhang,Yuanlin Guan,Dongqian Shen,Yangqing Peng,Dongya Zhang,Zhuye Jie,Wenxian Wu,Youwen Qin,Wenbin Xue,Junhua Li,Lingchuan Han,Donghui Lu,Peixian Wu,Yali Dai,Xiaojuan Sun,Zesong Li,Aifa Tang,Shilong Zhong,Xiaoping Li,Weineng Chen,Ran Xu,Mingbang Wang,Qiang Feng,Meihua Gong,Jing Yu,Yanyan Zhang,Ming Zhang,Torben Hansen,Gaston Sanchez,Jeroen Raes,Gwen Falony,Shujiro Okuda,Mathieu Almeida,Emmanuelle Le-chatelier,Pierre Renault,Nicolas Pons,Jean-Michel Batto,Zhaoxi Zhang,Hua Chen,Ruifu Yang,Wei-Mou Zheng,Songgang Li,Huanming Yang,Jian Wang,S. Dusko Ehrlich,Rasmus Nielsen,Oluf Pedersen,Oluf Pedersen,Karsten Kristiansen,Jun Wang +56 more
TL;DR: MGWAS analysis showed that patients with type 2 diabetes were characterized by a moderate degree of gut microbial dysbiosis, a decrease in the abundance of some universal butyrate-producing bacteria and an increase in various opportunistic pathogens, as well as an enrichment of other microbial functions conferring sulphate reduction and oxidative stress resistance.
Journal ArticleDOI
Open-Source Genomic Analysis of Shiga-Toxin–Producing E. coli O104:H4
Holger Rohde,Junjie Qin,Yujun Cui,Dongfang Li,Nicholas J. Loman,Moritz Hentschke,Wentong Chen,Fei Pu,Yangqing Peng,Junhua Li,Feng Xi,Shenghui Li,Yin Li,Zhaoxi Zhang,Xianwei Yang,Meiru Zhao,Peng Wang,Yuanlin Guan,Zhong Cen,Xiangna Zhao,Martin Christner,Robin Kobbe,Sebastian Loos,Jun Oh,Liang Yang,Antoine Danchin,George F. Gao,Yajun Song,Yingrui Li,Huanming Yang,Jian Wang,Jianguo Xu,Mark J. Pallen,Jun Wang,Martin Aepfelbacher,Ruifu Yang +35 more
TL;DR: A cluster of cases associated with a single family is reported and an open-source genomic analysis of an isolate from one member of the family is described, revealing that the outbreak strain belonged to an enteroaggregative E. coli lineage that had acquired genes for Shiga toxin 2 and for antibiotic resistance.
Journal ArticleDOI
ICE-CBF-COR Signaling Cascade and Its Regulation in Plants Responding to Cold Stress
Delight Tonderai Hwarari,Yuanlin Guan,Baseer Ahmad,Ali Movahedi,Tian Min,Zhaodong Hao,Ye Lu,Jinhui Chen,Liming Yang +8 more
TL;DR: A concise summary of the ICE-CBF-COR pathway elucidating on the cross interconnections with other repressors, inhibitors, and activators to induce cold stress acclimation in plants is provided.
Patent
Method and device for analyzing microbial community composition
Shenghui Li,Qiang Feng,Junjie Qin,Jianfeng Zhu,Yuanlin Guan,Jun Wang,Jian Wang,Huanming Yang +7 more
TL;DR: In this paper, a reference set comprising a plurality of sequences of polynucleotides of the sample is obtained, based on a relative abundance of each sequence of the reference set in the sample.
Journal ArticleDOI
Abnormal global alternative RNA splicing in COVID-19 patients
Changli Wang,Lijun Chen,Yaobin Chen,Wenwen Jia,Xunhui Cai,Yufeng Liu,Fenghu Ji,Peng Xiong,Anyi Liang,Yuanlin Guan,Zhong-Yi Cheng,Yejing Weng,Weixin Wang,Yaqi Duan,Dong-Ming Kuang,Sanpeng Xu,Hanghang Cai,Qin Xia,Dehua Yang,Ming-Wei Wang,Xiang-Ping Yang,Jianjun Zhang,Chao Cheng,Liang Liu,Zhongmin Liu,Ren Liang,Guoping Wang,Zhen-dong Li,Han Xia,Tian Xia +29 more
TL;DR: The transcriptome analysis showed that SARS-CoV-2 infection induces widespread dysregulation of transcript usage and expression, affecting blood coagulation, neutrophil activation, and cytokine production, and splice-variants may contribute to unexpected therapeutic activity.