scispace - formally typeset
Search or ask a question
Institution

Binzhou Medical College

EducationYantai, China
About: Binzhou Medical College is a education organization based out in Yantai, China. It is known for research contribution in the topics: Apoptosis & Cancer. The organization has 959 authors who have published 619 publications receiving 7642 citations.
Topics: Apoptosis, Cancer, Cell growth, Metastasis, Genotype


Papers
More filters
Journal ArticleDOI
TL;DR: Findings indicate that Rev-D4F has an important vasculoprotective role in ALI by improving the EPC numbers and functions, and Rev- D4F reverses LPS-induced EPC dysfuncion partially through PI3K/AKT/eNOS signaling pathway.
Abstract: Patients with acute lung injury (ALI) have increased levels of pro-inflammatory mediators, which impair endothelial progenitor cell (EPC) function. Increasing the number of EPC and alleviating EPC dysfunction induced by pro-inflammatory mediators play important roles in suppressing ALI development. Because the high density lipoprotein reverse-D-4F (Rev-D4F) improves EPC function, we hypothesized that it might repair lipopolysaccharide (LPS)-induced lung damage by improving EPC numbers and function in an LPS-induced ALI mouse model. LPS was used to induce ALI in mice, and then the mice received intraperitoneal injections of Rev-D4F. Immunohistochemical staining, flow cytometry, MTT, transwell, and western blotting were used to assess the effect of Rev-D4F on repairment of lung impairment, and improvement of EPC numbers and function, as well as the signaling pathways involved. Rev-D4F inhibits LPS-induced pulmonary edema and decreases plasma levels of the pro-inflammatory mediators TNF-α and ET-1 in ALI mice. Rev-D4F inhibited infiltration of red and white blood cells into the interstitial space, reduced lung injury-induced inflammation, and restored injured pulmonary capillary endothelial cells. In addition, Rev-D4F increased numbers of circulating EPC, stimulated EPC differentiation, and improved EPC function impaired by LPS. Rev-D4F also acted via a PI3-kinase-dependent mechanism to restore levels of phospho-AKT, eNOS, and phospho-eNOS suppressed by LPS. These findings indicate that Rev-D4F has an important vasculoprotective role in ALI by improving the EPC numbers and functions, and Rev-D4F reverses LPS-induced EPC dysfuncion partially through PI3K/AKT/eNOS signaling pathway.

15 citations

Journal ArticleDOI
TL;DR: This study assesses the stratum corneum (SC) hydration in sun‐exposed males and females and demonstrates that sun‐induced alteration of epidermal permeability barrier function varies with gender and age.
Abstract: Background/objectives: Previous studies have demonstrated that sun-induced alteration of epidermal permeability barrier function varies with gender and age. In the present study, we assess the stratum corneum (SC) hydration in sun-exposed males and females. Methods: A total of 168 subjects (84 males and 84 females) aged 19–75 years were enrolled. A multifunctional skin physiology monitor was used to measure SC hydration. Results: In comparison with non-sun exposure, sun exposure does not cause a significant change in SC hydration in either young males or young females, whereas in aged females, a significant reduction of SC hydration is seen on the forehead and the dorsal hand of sun-exposed subjects. SC hydration on the canthus of both aged males and aged females is significantly lower than that of young subjects. Additionally, SC hydration on the dorsal hand of aged females is also significantly lower as compared with young females. Sun-induced reduction of SC hydration is more evident on the dorsal hand of aged females than that of males (P<0.001). Moreover, the SC rehydration capacity is significantly lower in sun-exposed aged females than in age-matched males. Conclusion: These results demonstrated that sun-induced changes of the SC hydration property vary with age and gender.

15 citations

Journal ArticleDOI
TL;DR: In many studies about biomedical research factors influence on the outcome variable, it has no influence or has a positive effect within a certain range, but above a certain threshold value, the size of the effect and/or orientation will change, which called threshold effect.
Abstract: In many studies about biomedical research factors influence on the outcome variable, it has no influence or has a positive effect within a certain range. Exceeding a certain threshold value, the size of the effect and/or orientation will change, which called threshold effect. Whether there are threshold effects in the analysis of factors (x) on the outcome variable (y), it can be observed through a smooth curve fitting to see whether there is a piecewise linear relationship. And then using segmented regression model, LRT test and Bootstrap resampling method to analyze the threshold effect. Empower Stats software developed by American X & Y Solutions Inc has a threshold effect analysis module. You can input the threshold value at a given threshold segmentation simulated data. You may not input the threshold, but determined the optimal threshold analog data by the software automatically, and calculated the threshold confidence intervals.

15 citations

Journal Article
TL;DR: Students who experienced childhood sexual abuses got higher scores than the students who didn't have such experience in the nine basic symptom factors of SCL-90 and higher than normal model of national young group notably.
Abstract: OBJECTIVE: To survey the occurrence of childhood sexual abuses (CSA) among adult students and analyze the correlation between the sexual abuses and the results of Symptom Check-List-90 (SCL-90) test. METHODS: Questionnaire survey of 1307 adult students (701 female students, 606 male students) in a college about their personal experience on childhood sexual abuses. The surveys were conducted anonymously. And SCL-90 test was carried out at the same time. RESULTS: A total of 1307 students were surveyed. 18.67% of them (female students, 155, 22.11%; male students, 89, 14.69%) experienced non-physical contact sexual abuses and/or physical contact sexual abuses before the age of 18 years, among whom 124 students (female students, 81, 11.55%; male students, 44, 7.26%) experienced physical contact sexual abuses, including 35 (26 female; 9 male) who suffered attempted genital or anal sexual intercourse and 11 (8 female and 3 male) were forced for genital or anal sexual intercourse; 13.70% (female 15.66%; male 11.44%) said they experienced sexual abuses before the age of 16 years. Of the boys, experienced sexual abuse 54.7% from age 12 to age 16 years. And among the girls sexual abuses tended to increase with their growth (results of tendency test: chi(2) = 33.5, P Language: zh

15 citations

Journal ArticleDOI
TL;DR: Wang et al. as discussed by the authors investigated the actual long-term survival and its associated prognostic factors after liver resection for hepatocellular carcinoma (HCC) patients with microvascular invasion.
Abstract: Microvascular invasion (MVI) is a risk factor for postoperative survival outcomes for hepatocellular carcinoma (HCC) after liver resection (LR) This study aims to investigate the actual long-term survival and its associated prognostic factors after LR for HCC patients with MVI This study was conducted on HCC patients with MVI who underwent LR from January 2009 to December 2012 at five major hospitals in China The patients were divided into the ‘long-term survivor group’ and the ‘short-term survivor group’ The clinicopathologic characteristics, perioperative data and survival outcomes were compared between these two groups Univariate and multivariate regression analyses were performed to identify predictive factors associated with long-term survival outcomes The study included 1517 patients with an actual 5-year survival rate of 333% Multivariate regression analysis revealed that HBV DNA > 104 IU/mL, alanine aminotransferase > 44 U/L, alpha-fetoprotein > 400 ng/ml, anatomical hepatectomy, varices, intraoperative blood loss > 400 ml, tumor diameter > 5 cm, tumor number, satellite nodules, tumor encapsulation, wide resection margin and adjuvant transarterial chemoembolization (TACE) were independent prognostic factors associated with actual long-term survival One-third of HCC patients with MVI reached the long-term survival milestone of 5 years after resection Anatomical hepatectomy, controlling intraoperative blood loss, a wide resection margin, and postoperative adjuvant TACE should be considered for patients to achieve better long-term survival outcomes

15 citations


Authors

Showing all 959 results

NameH-indexPapersCitations
Yuming Guo7349237180
Mingwen Zhao5536110884
Philip H.-S. Jen301373644
Qiusheng Zheng281172352
Qiang Fu19621094
Haixia Zhang17381155
Ling-Qun Kong1520931
Xuemei Hu1430395
Jichun Han1428447
Bao-guang Hu1120732
Xianbing Liu1121301
Xiaoyan Xu1015260
Yongfeng Gong1010521
Jingjing Xie1013457
Xiling Sun1018404
Network Information
Related Institutions (5)
Harbin Medical University
18.1K papers, 330.9K citations

79% related

Second Military Medical University
20.4K papers, 449.4K citations

78% related

Third Military Medical University
18.2K papers, 354.1K citations

78% related

Capital Medical University
47.2K papers, 811.2K citations

78% related

Fourth Military Medical University
20.7K papers, 425.5K citations

78% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20223
202136
202039
201932
201824
201739