Institution
Binzhou Medical College
Education•Yantai, China•
About: Binzhou Medical College is a education organization based out in Yantai, China. It is known for research contribution in the topics: Apoptosis & Cancer. The organization has 959 authors who have published 619 publications receiving 7642 citations.
Topics: Apoptosis, Cancer, Cell growth, Metastasis, Genotype
Papers published on a yearly basis
Papers
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TL;DR: The results indicated that metformin displays anticancer activity against lung adenocarcinoma by causing G1 arrest of the cell cycle and subsequent cell apoptosis through the mitochondria-dependent pathway in A549 cells, and suggested that meetformin may become a potential cytotoxic drug in the prevention and treatment of lungAdenocARCinoma.
Abstract: Metformin is commonly used to treat type II diabetes, although it may also reduce the risk of cancer and improve the associated prognosis. However, its mode of action in cancer remains unclear. The present study evaluated the effects of metformin on lung adenocarcinoma A549 cells and identified molecular mechanisms of metformin activity. The A549 cells were treated with metformin at different concentrations and cell viability was assayed by using an MTT assay. The cell cycle and the apoptosis rate were assayed by flow cytometry. Nude mice were transplanted with A549 cells and the tumor growth inhibition rate was detected. Once the A549 cells had been treated with 20 mM metformin for 48 h, the cell cycle was arrested in the G0/Gl phase and the apoptosis rate was 20.57±3.16%. The expression of the B-cell lymphoma (Bcl)-2 and Bcl-extra large proteins was downregulated following metformin treatment, while Bax protein expression was significantly increased. Tumor size in the high-dose metformin and cisplatin plus metformin groups was significantly smaller, and the inhibition rates were 41.3 and 72.9%, respectively, compared with the control group. These results indicated that metformin displays anticancer activity against lung adenocarcinoma by causing G1 arrest of the cell cycle and subsequent cell apoptosis through the mitochondria-dependent pathway in A549 cells. Furthermore, it was found that metformin dramatically inhibited lung adenocarcinoma tumor growth in vivo. These data suggest that metformin may become a potential cytotoxic drug in the prevention and treatment of lung adenocarcinoma.
33 citations
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TL;DR: Peniciketals A-C (1-3), three new spiroketals with a benzo-fused 2,8-dioxabicyclo[3.3.1]nonane moiety, were isolated from the saline soil derived fungus Penicillium raistrichii and their structures including absolute configurations were established by NMR, X-ray diffraction, and ECD calculations.
32 citations
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Shanghai Jiao Tong University1, Huazhong University of Science and Technology2, Shanghai Chest Hospital3, Central South University4, Harbin Medical University5, Peking Union Medical College6, Xinxiang Medical University7, Binzhou Medical College8, Zhengzhou University9, Wenzhou Medical College10, Xinjiang Medical University11, Sun Yat-sen University12, Qingdao University13, Jilin University14
TL;DR: A novel, irreversible epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI) with favorable pharmacologic properties that selectively inhibits both EGFR sensiti...
Abstract: 9013Background: Au is a novel, irreversible epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI) with favorable pharmacologic properties that selectively inhibits both EGFR sensiti...
32 citations
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TL;DR: The correlation between IL‐35 expression in tumor‐infiltrating lymphocytes (TILs) of breast cancer tissue and patients' clinical characteristics was analyzed and it was shown that patients with elevated IL‐ 35 expression in TILs had significantly worse progression‐free survival (PFS) and overall survival (OS) than patients with weak or no IL-35 expression.
32 citations
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TL;DR: The results showed that rapamycin treatment significantly reduced the infarct volume, the water content of the brain tissue and the Evans blue extravasation through the blood–brain barrier (BBB), and inhibited matrix metalloproteinase 9 and aquaporin 4 expression, implying thatRapamycin could improve brain edema progression after reperfusion injury through maintaining BBB integrity and inhibiting MMP9 and AQP4 expression.
Abstract: Brain edema is a major consequence of cerebral ischemia reperfusion. However, few effective therapeutic options are available for retarding the brain edema progression after cerebral ischemia. Recently, rapamycin has been shown to produce neuroprotective effects in rats after cerebral ischemia reperfusion. Whether rapamycin could alleviate this brain edema injury is still unclear. In this study, the rat stroke model was induced by a 1-h left transient middle cerebral artery occlusion using an intraluminal filament, followed by 48 h of reperfusion. The effects of rapamycin (250 μg/kg body weight, intraperitoneal; i.p.) on brain edema progression were evaluated. The results showed that rapamycin treatment significantly reduced the infarct volume, the water content of the brain tissue and the Evans blue extravasation through the blood–brain barrier (BBB). Rapamycin treatment could improve histological appearance of the brain tissue, increased the capillary lumen space and maintain the integrity of BB...
31 citations
Authors
Showing all 959 results
Name | H-index | Papers | Citations |
---|---|---|---|
Yuming Guo | 73 | 492 | 37180 |
Mingwen Zhao | 55 | 361 | 10884 |
Philip H.-S. Jen | 30 | 137 | 3644 |
Qiusheng Zheng | 28 | 117 | 2352 |
Qiang Fu | 19 | 62 | 1094 |
Haixia Zhang | 17 | 38 | 1155 |
Ling-Qun Kong | 15 | 20 | 931 |
Xuemei Hu | 14 | 30 | 395 |
Jichun Han | 14 | 28 | 447 |
Bao-guang Hu | 11 | 20 | 732 |
Xianbing Liu | 11 | 21 | 301 |
Xiaoyan Xu | 10 | 15 | 260 |
Yongfeng Gong | 10 | 10 | 521 |
Jingjing Xie | 10 | 13 | 457 |
Xiling Sun | 10 | 18 | 404 |