Institution
Binzhou Medical College
Education•Yantai, China•
About: Binzhou Medical College is a education organization based out in Yantai, China. It is known for research contribution in the topics: Apoptosis & Cancer. The organization has 959 authors who have published 619 publications receiving 7642 citations.
Topics: Apoptosis, Cancer, Cell growth, Metastasis, Genotype
Papers published on a yearly basis
Papers
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TL;DR: The PCFS is associated with the differentiation of epithelium and involved in gastric carcinogenesis via epithelial-mesenchymal interaction and was gradually reduced in IM, Dys and GC in sequence.
Abstract: To investigate the existence of pericryptal fibroblasts sheath (PCFS) in normal gastric mucosa, intestinal metaplasia (IM), indefinite for dysplasia (I-Dys), low grade dysplasia (L-Dys), high grade dysplasia (H-Dys) and gastric cancer (GC), and its association with gastric carcinogenesis. In this study, we examined the existence of PCFS in normal gastric mucosa (N=10), IM (N=26), I-Dys (N=16), L-Dys (N=13), H-Dys (N=21) and GC (N=145) using immunohistochemical staining for two smooth muscle markers, alpha smooth muscle actin(α-SMA) and high molecular weight caldesmon (h-CD). The significance of PCFS was discussed, especially in association with gastric carcinogenesis. The PCFS was recognized in 65.4%(17/26) of IM, 62.5%(10/16) of I-Dys and 23.1% (3/13) of L-Dys respectively. No PCFS was detected in H-Dys and GC. The PCFS was gradually reduced in IM, Dys and GC in sequence (P<0.0001). The PCFS is associated with the differentiation of epithelium and involved in gastric carcinogenesis via epithelial-mesenchymal interaction.
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TL;DR: In the title compound, C22H19NOS2, the thiophene rings form angles of 69.74 (18) and 65.56”(16)° with the benzene ring and the piperidone ring adopts a half-chair conformation due to the presence of the conjugated ketone systems.
Abstract: In the title compound, C22H19NOS2, the thiophene rings form angles of 69.74 (18) and 65.56 (16)° with the benzene ring. The piperidone ring adopts a half-chair conformation due to the presence of the conjugated ketone systems. Both thiophene rings are disordered over two orientations [occupancies of 0.758 (2)/0.242 (2) and 0.588 (2)/0.412 (2)] at 180° from one another. In the crystal, weak intermolecular C—H⋯O hydrogen bonds, C—H⋯π and aromatic π–π stacking interactions [shortest centroid–centroid separation = 3.865 (3) A] help to stabilize the packing.
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TL;DR: In this paper, the authors designed and synthesized a series of derivatives as potent highly biased MOR agonists (19a-v) through the modification and structure-activity relationship study of TRV130.
Authors
Showing all 959 results
Name | H-index | Papers | Citations |
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Yuming Guo | 73 | 492 | 37180 |
Mingwen Zhao | 55 | 361 | 10884 |
Philip H.-S. Jen | 30 | 137 | 3644 |
Qiusheng Zheng | 28 | 117 | 2352 |
Qiang Fu | 19 | 62 | 1094 |
Haixia Zhang | 17 | 38 | 1155 |
Ling-Qun Kong | 15 | 20 | 931 |
Xuemei Hu | 14 | 30 | 395 |
Jichun Han | 14 | 28 | 447 |
Bao-guang Hu | 11 | 20 | 732 |
Xianbing Liu | 11 | 21 | 301 |
Xiaoyan Xu | 10 | 15 | 260 |
Yongfeng Gong | 10 | 10 | 521 |
Jingjing Xie | 10 | 13 | 457 |
Xiling Sun | 10 | 18 | 404 |