Binzhou Medical College

About: Binzhou Medical College is a education organization based out in Yantai, China. It is known for research contribution in the topics: Apoptosis & Cancer. The organization has 959 authors who have published 619 publications receiving 7642 citations.

Zebrafish xenotransplantation as a tool for in vivo cancer study

Abstract: Zebrafish represents a powerful model for cancer research. Particularly, the xenotransplantation of human cancer cells into zebrafish has enormous potential for further evaluation of cancer progression and drug discovery. Various cancer models have been established in adults, juveniles and embryos of zebrafish. This xenotransplantation zebrafish model provides a unique opportunity to monitor cancer proliferation, tumor angiogenesis, metastasis, self-renewal of cancer stem cells, and drug response in real time in vivo. This review summarizes the use of zebrafish as a model for cancer xenotransplantation, and highlights its advantages and disadvantages.

Hydroxysafflor yellow A suppresses liver fibrosis induced by carbon tetrachloride with high-fat diet by regulating PPAR-γ/p38 MAPK signaling

Abstract: Context: One approach to protect against liver fibrosis is the use of herb-derived natural compounds, such as hydroxysafflor yellow A (HSYA) The antifibrosis effect of HYSA against liver fibrosis has been investigated; however, its mechanisms have not yet been entirely revealedObjectives: To study the protective effects of HSYA on liver fibrosis induced by carbon tetrachloride (CCl4) and a high-fat diet (HFD), and to determine the mechanism of action of HSYAMaterials and methods: CCl4 and HFD were used to mimic liver fibrosis in rats, and serum biochemical indicators were determined The antifibrosis effects of HSYA were evaluated and its mechanisms were investigated by histopathological analysis, immunohistochemical staining, enzyme-linked immunosorbent assays, real-time-PCR, and western blottingResults: HSYA reduced CCl4- and HFD-mediated liver fibrosis and ameliorated serum biochemical indicator, downregulated the expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) (031 ± 003 p

The effects of polyethylene glycol (PEG) as an electrolyte additive on the corrosion behavior and electrochemical performances of pure aluminum in an alkaline zincate solution

Abstract: The effects of zinc oxide and/or polyethylene glycol (PEG) as electrolyte additives on the corrosion and electrochemical performances of pure aluminum in 4.0?M KOH solutions were investigated by means of hydrogen collection, polarization curve, galvanostatic discharge, scanning electron microscopy (SEM), and energy dispersive analysis of X-ray (EDAX). The addition of ZnO markedly inhibited the corrosion of aluminum in 4.0?M KOH solutions, resulting from the deposition of zinc with high hydrogen evolution overpotential in aluminum surfaces. The introduction of PEG in the alkaline zincate solution obviously improved the deposition of zinc by increase in the overpotential of zinc deposition, thus the corrosion rate of aluminum in the alkaline zincate solutions with PEG was further decreased. The enhancement effect of PEG on the inhibition of zinc oxide first increased and then decreased with increasing the content of PEG in the electrolyte. The electrolyte system with 0.2?M ZnO and 2.0?mM PEG presented the highest inhibition efficiency (98.8%) for the corrosion of aluminum. The results of galvanostatic discharge indicated that the aluminum anode shows excellent discharge performances in the 4.0?M KOH solution with 0.2?M ZnO and 2.0?mM PEG.

Effects of Atorvastatin on Pathological Changes in Brain Tissue and Plasma MMP-9 in Rats with Intracerebral Hemorrhage

Abstract: To explore the effects of atorvastatin on hydrocephalus, neurocyte apoptosis, and the level of plasma matrix metalloproteinase-9 (MMP-9) after intracerebral hemorrhage (ICH) in rats. A rat model of ICH was established by intracerebral injection of collagenase. The brain water content was determined by the wet/dry weight ratio, ultrastructural changes in brain tissue were observed by electron microscopy, and the level of plasma MMP-9 was quantified by ELISA. Atorvastatin showed significant effects in reducing the brain water content, blocking neuron apoptosis, and decreasing plasma MMP-9 in rats with ICH. There was a positive linear correlation between plasma MMP-9 and the brain water content. Atorvastatin can significantly relieve brain edema, decrease the brain injury caused by MMP-9 and protect neurons in rats with ICH.