Institution
Binzhou Medical College
Education•Yantai, China•
About: Binzhou Medical College is a education organization based out in Yantai, China. It is known for research contribution in the topics: Apoptosis & Cancer. The organization has 959 authors who have published 619 publications receiving 7642 citations.
Topics: Apoptosis, Cancer, Cell growth, Metastasis, Genotype
Papers published on a yearly basis
Papers
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TL;DR: The current investigation revealed that the crocetin reduced the HCD induced dyslipidemia in the Wistar rats, the possible mechanism of action may be connected to the antioxidative, down regulating of p-p38 MAPK and antiinflammatory effect by cro cetin.
26 citations
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TL;DR: The data showed a strong dose–response relationship between ISL exposure and the characteristics of HL‐60 differentiation, namely, morphology changes, NBT reductive activities, and expression levels of surface antigens CD11b/CD14.
26 citations
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TL;DR: The results indicate that serum and colonic omentin-1 expressions are decreased in active CD patients, and the correlation of serum oment in-1 with disease activity in CD is superior to that of CRP.
Abstract: Background and Aim. It remains challenging to determine the inflammatory activity in Crohn's disease (CD) for lack of specific laboratory markers. Recent studies suggest that serum omentin-1 is associated with inflammatory response. We aimed to assess the potential of serum omentin-1 as a marker of disease activity in CD patients. Methods. Serum omentin-1 concentrations were determined by enzyme-linked immunosorbent assay (ELISA) in patients with CD (n = 240), functional gastrointestinal disorders (FGDs, n = 120), and healthy controls (HC, n = 60) and evaluated for correlation with disease activity. Expression of omentin-1 in colonic tissues from patients with CD was also analyzed by real-time PCR and Western blotting. Serum omentin-1 levels as an activity index were evaluated using a receiver operating characteristic (ROC) curve. Results. Serum omentin-1 concentrations were significantly decreased in active CD patients compared with patients in remission, FGDs, and HC (all P < 0.001). Expression of omentin-1 was decreased at mRNA and protein levels in inflamed colonic tissues in active CD than that in noninflamed colonic tissues. Serum omentin-1 levels were negatively correlated with disease activity in CD, better than C-reactive protein (CRP). Conclusion. Our results indicate that serum and colonic omentin-1 expressions are decreased in active CD patients. The correlation of serum omentin-1 with disease activity in CD is superior to that of CRP. Serum omentin-1 is a potential marker for CD disease activity.
26 citations
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TL;DR: It is shown that LDE significantly suppressed the in vitro melanoma cell growth in dose- and time-dependent manners, and may have a wide therapeutic and/or adjuvant therapeutic application in the treatment of melanoma and other cancer.
Abstract: The purpose of this study is to investigate the effects of Lang-du extract (LDE) from Traditional Chinese Medicine (TCM) Euphorbia fischeriana Steud on the in vitro and in vivo growth of melanoma cells and its molecular mechanisms of action. Our present results have shown that LDE significantly suppressed the in vitro melanoma cell growth in dose- and time-dependent manners. LDE also displayed the synergistic effect with γ-radiation on the reduction of the cell viability in melanoma cells. The animal experimental results further confirmed that compared with the control group without drug treatment, the tumor volume in mice was significantly and time-dependently less in LDE group. The absolute weight of solid tumor in the LDE group was 7-fold lower than that in the control group. Western blot analysis indicated that LDE markedly down-regulated the expression of anti-apoptotic protein Bcl-2 and up-regulated the level of pro-apoptotic protein Bax, eventually leading the reduction of Bcl-2/Bax protein ratios both in the cultured melanoma cells and in the tumors from melanoma-bearing mice. In addition, LDE significantly reduced the tumor progression-associated protein levels of vascular endothelial growth factor (VEGF), hepatocyte growth factor/scatter factor (HGF/SF), and osteopontin (OPN) in tumors from the LDE-treated mice. Our findings suggest that LDE may have a wide therapeutic and/or adjuvant therapeutic application in the treatment of melanoma and other cancer.
26 citations
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TL;DR: In this article, six new compounds, named peneciraistins A-F (1−6), were isolated from saline soil derived fungus Penicillium raistrickii.
26 citations
Authors
Showing all 959 results
Name | H-index | Papers | Citations |
---|---|---|---|
Yuming Guo | 73 | 492 | 37180 |
Mingwen Zhao | 55 | 361 | 10884 |
Philip H.-S. Jen | 30 | 137 | 3644 |
Qiusheng Zheng | 28 | 117 | 2352 |
Qiang Fu | 19 | 62 | 1094 |
Haixia Zhang | 17 | 38 | 1155 |
Ling-Qun Kong | 15 | 20 | 931 |
Xuemei Hu | 14 | 30 | 395 |
Jichun Han | 14 | 28 | 447 |
Bao-guang Hu | 11 | 20 | 732 |
Xianbing Liu | 11 | 21 | 301 |
Xiaoyan Xu | 10 | 15 | 260 |
Yongfeng Gong | 10 | 10 | 521 |
Jingjing Xie | 10 | 13 | 457 |
Xiling Sun | 10 | 18 | 404 |